血清脂联素浓度与慢性阻塞性肺疾病的关系：一项荟萃分析。

Association between serum adiponectin concentrations and chronic obstructive pulmonary disease: a meta-analysis.

机构信息

Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China.

Outpatient Department, the First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China.

出版信息

Biosci Rep. 2020 Mar 27;40(3). doi: 10.1042/BSR20192234.

BACKGROUND

Adiponectin has been implicated to play a role in the pathophysiology of chronic obstructive pulmonary disease (COPD). Many studies have assessed serum adiponectin concentrations in COPD patients. However, results from different reports were not consistent. To assess the association of serum adiponectin concentrations and COPD, a meta-analysis was performed.

METHODS

PubMed, Embase, Web of Science and Cochrane Library were searched for eligible studies. Data were extracted, and then standard mean differences (SMDs) and 95% confidence intervals (CI) were calculated.

RESULTS

Thirteen studies involving a total of 1131 cases and 689 controls were included in this meta-analysis. Combined data indicated that the serum adiponectin levels were higher in COPD patients than those in controls (SMD: 1.09, 95% CI [0.73-1.45], P < 0.001). In the subgroup analyses by disease period, there were similar results in stable COPD patients (SMD: 0.77, 95% CI [0.47-1.07], p <0.001; I2 = 83.9%, P < 0.001), AECOPD patients (SMD: 2.51, 95% CI [0.71-4.30], P = 0.006; I2 = 95.2%, P < 0.001) and mixed COPD patients (SMD: 1.21, 95% CI [0.67-1.75], P < 0.001). Furthermore, the serum adiponectin levels were higher in AECOPD patients than those in stable COPD patients (SMD: 1.06, 95% CI [0.13-1.99], P = 0.026).

CONCLUSIONS

This meta-analysis indicates that patients with COPD have higher serum adiponectin concentration than healthy controls.

背景

脂联素在慢性阻塞性肺疾病（COPD）的病理生理学中起作用。许多研究评估了 COPD 患者的血清脂联素浓度。然而，不同报告的结果并不一致。为了评估血清脂联素浓度与 COPD 的关系，进行了一项荟萃分析。

方法

检索 PubMed、Embase、Web of Science 和 Cochrane Library 以获取合格的研究。提取数据后，计算标准均数差（SMD）和 95％置信区间（CI）。

结果

共有 13 项研究纳入了总共 1131 例病例和 689 例对照者，进行了这项荟萃分析。合并数据表明，COPD 患者的血清脂联素水平高于对照组（SMD：1.09，95％CI [0.73-1.45]，P < 0.001）。在按疾病时期进行的亚组分析中，稳定期 COPD 患者也有类似的结果（SMD：0.77，95％CI [0.47-1.07]，p <0.001；I2 = 83.9％，P < 0.001）、AECOPD 患者（SMD：2.51，95％CI [0.71-4.30]，P = 0.006；I2 = 95.2％，P < 0.001）和混合 COPD 患者（SMD：1.21，95％CI [0.67-1.75]，P < 0.001）。此外，AECOPD 患者的血清脂联素水平高于稳定期 COPD 患者（SMD：1.06，95％CI [0.13-1.99]，P = 0.026）。