Department of Clinical Sciences Lund, Orthopaedics, Lund University, Lund, Sweden.
Arthro Therapeutics, Malmö, Sweden.
PLoS One. 2020 Mar 4;15(3):e0229783. doi: 10.1371/journal.pone.0229783. eCollection 2020.
Osteoarthritis (OA) is highly prevalent in older adults and a growing cause of disability. Easily accessible first-line treatment of OA is increasingly important. Digital self-management programs have in recent years become available. Evidence of short-term effects of such programs are abundant, yet reports on long-term benefits and adherence to treatment are scarce. The current study's objective was to investigate the long-term pain and function outcomes of people with hip or knee OA participating in a digital self-management programme.
In this longitudinal cohort study, individuals with hip and knee OA, from the register of a digital self-management program and with 0-24-week (n = 499) or 0-48-week adherence (n = 138), were included. The treatment effect in terms of monthly pain (NRS, 0-10 worst to best) and physical function (30-second chair stand test (30CST), number of repetitions) change were investigated using a mixed model, controlling for the effect of age, body mass index (BMI), gender and index joint. For the 24-week sub-sample, pain NRS decreased monthly by -0.43 units (95% CI -0.51, -0.35, mean knee pain from 5.6 to 3.1, and hip pain from 5.9 to 3.8) and 30CST repetitions increased monthly by 0.76 repetitions (95% CI 0.64, 0.89 mean for knee from 10.0 to 14.3, and for hip from 10.9 to 14.8). For the 48-week sub-sample, pain decreased monthly by -0.39 units (95% CI -0.43, -0.36, mean knee pain from 5.7 to 3.2, and hip pain from 5.8 to 3.8), and repetitions increased by 0.72 repetitions (95% CI 0.65, 0.79, mean repetitions for knee from 10.3 to 14.4, and for hip from 11.1 to 14.9). There were no clinically relevant effects on the improvement of pain or function by any covariate (age, sex, index joint). The lack of a control group and randomization limit our ability to explain the mechanisms of the observed results.
Continuously participating in a digital OA treatment program for 6 or 12 months was associated with a clinically important decrease in joint pain and increased physical function, in hip and knee OA. Future research should follow OA-related outcomes in participants that end their treatment to explore when and why that decision was made.
骨关节炎(OA)在老年人中高发,且是导致残疾的主要原因之一。OA 的一线治疗方法简单易用,其应用越来越广泛。近年来,数字自我管理项目层出不穷。此类项目短期效果的证据较为充分,但关于长期获益和治疗依从性的报告却很少。本研究旨在探究参与数字自我管理项目的髋或膝关节 OA 患者的长期疼痛和功能结局。
本纵向队列研究纳入了数字自我管理项目登记处的髋和膝关节 OA 患者,入组患者的随访时间为 0-24 周(n=499)或 0-48 周(n=138)。采用混合模型分析每月疼痛(NRS,0-10 分,最差至最佳)和身体功能(30 秒椅子站立试验(30CST),重复次数)的治疗效果,控制年龄、体重指数(BMI)、性别和索引关节的影响。对于 24 周亚组,疼痛 NRS 每月下降 0.43 个单位(95%CI:-0.51,-0.35,膝关节疼痛从 5.6 降至 3.1,髋关节疼痛从 5.9 降至 3.8),30CST 重复次数每月增加 0.76 次(95%CI:0.64,0.89,膝关节从 10.0 增加到 14.3,髋关节从 10.9 增加到 14.8)。对于 48 周亚组,疼痛每月下降 0.39 个单位(95%CI:-0.43,-0.36,膝关节疼痛从 5.7 降至 3.2,髋关节疼痛从 5.8 降至 3.8),重复次数增加 0.72 次(95%CI:0.65,0.79,膝关节从 10.3 增加到 14.4,髋关节从 11.1 增加到 14.9)。任何协变量(年龄、性别、索引关节)均未对疼痛或功能改善产生明显的临床相关影响。由于缺乏对照组和随机分组,我们无法解释观察结果的机制。
髋或膝关节 OA 患者持续参与 6 或 12 个月的数字 OA 治疗方案,与关节疼痛的显著减轻和身体功能的显著改善相关。未来的研究应关注结束治疗的 OA 患者的 OA 相关结局,以探究他们停止治疗的时间和原因。