Universidade Federal da Bahia, Programa de Pós-Graduação em Ciências da Saúde, Salvador, BA, Brasil.
Universidade Federal da Bahia, Serviço de Imunologia, Salvador, BA, Brasil.
Mem Inst Oswaldo Cruz. 2020 Mar 2;115:e190361. doi: 10.1590/0074-02760190361. eCollection 2020.
Genes associated with wound healing have been shown to be risk factors for cutaneous leishmaniasis (CL) which is caused by Leishmania braziliensis. In this study, we examined whether the genes previously associated with CL influenced the clinical outcome. Patients were genotyped and retrospectively classified as responders, who were cured with a single course of pentavalent antimony (Sbv), or as refractories, who did not respond to Sbv. Patients characterised as responders showed a stronger response to the leishmanin skin test (LST) when compared to the refractory subjects (p = 0.0003). Furthermore, we observed an association between the FLI1 CC genotype and an increased size of ulcers (p = 0.0170). We suggest that the leishmanin skin test may be a predictive tool for therapeutic outcome and reinforce FLI1 as a potential influencer of susceptibility and lesion size in CL.
已证实与伤口愈合相关的基因是巴西利什曼原虫引起的皮肤利什曼病 (CL) 的风险因素。在这项研究中，我们研究了先前与 CL 相关的基因是否影响临床结果。对患者进行基因分型，并回顾性地将其分类为对单剂五价锑 (Sbv) 治疗有反应的应答者，或对 Sbv 无反应的难治者。与难治者相比，应答者对利什曼原菌素皮肤试验 (LST) 的反应更强 (p = 0.0003)。此外，我们还观察到 FLI1 CC 基因型与溃疡面积增大之间存在关联 (p = 0.0170)。我们认为，利什曼原菌素皮肤试验可能是一种预测治疗效果的工具，并进一步证实 FLI1 是 CL 易感性和病变大小的潜在影响因素。
