Beck Amanda P, Meyerholz David K
Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA.
Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA, USA.
Cell Tissue Res. 2020 May;380(2):305-311. doi: 10.1007/s00441-019-03134-3. Epub 2020 Mar 4.
Animal models are a significant component of biomedical research and play an important role in translational studies. Traditionally, rodent models have been the mainstay and principal choice of researchers but in recent years, there have been significant changes in the landscape of animal modeling. For example, newer techniques have greatly expanded the use and successful application of large animal models such as pigs for translational studies. The evolving types and species of animal models can influence the research landscape in terms of facilities, expertise, reproducibility and funding streams, which creates new challenges for research studies. It is also important that investigators are prepared to address the necessity of their animal model research and capable to educate the public regarding its value.
动物模型是生物医学研究的重要组成部分，在转化研究中发挥着重要作用。传统上，啮齿动物模型一直是研究人员的主要支柱和首选，但近年来，动物建模领域发生了重大变化。例如，新技术极大地扩展了大型动物模型（如猪）在转化研究中的使用和成功应用。动物模型不断演变的类型和物种会在设施、专业知识、可重复性和资金流方面影响研究格局，这给研究带来了新的挑战。同样重要的是，研究人员要准备好阐述其动物模型研究的必要性，并能够向公众宣传其价值。
