Université catholique de Louvain (UCLouvain), Louvain Drug Research Institute, Brussels, Belgium.
Biomedical Magnetic Resonance, Brussels, Belgium.
Adv Exp Med Biol. 2020;1219:109-123. doi: 10.1007/978-3-030-34025-4_6.
Dysregulated metabolism is a key hallmark of cancer cells and an enticing target for cancer treatment. Since the last 10 years, research on cancer metabolism has moved from pathway attention to network consideration. This metabolic complexity continuously adapt to new constraints in the tumor microenvironment. In this review, we will highlight striking changes in cancer cell metabolism compared to normal cells. Understanding this tumor metabolic plasticity suggests potential new targets and innovative combinatorial treatments for fighting cancer.
代谢失调是癌细胞的一个关键特征，也是癌症治疗的一个诱人靶点。在过去的 10 年中，癌症代谢的研究已经从关注途径转变为考虑网络。这种代谢复杂性不断适应肿瘤微环境中的新约束。在这篇综述中，我们将强调与正常细胞相比，癌细胞代谢的显著变化。了解这种肿瘤代谢可塑性为对抗癌症提供了新的潜在靶点和创新的联合治疗方法。
