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Diagnostic deep-targeted next-generation sequencing assessment of TP53 gene mutations in multiple myeloma from the whole bone marrow.

作者信息

Petrackova Anna, Minarik Jiri, Sedlarikova Lenka, Libigerova Tereza, Hamplova Alzbeta, Krhovska Petra, Balcarkova Jana, Pika Tomas, Papajik Tomas, Kriegova Eva

机构信息

Department of Immunology, Faculty of Medicine and Dentistry, Palacky University and University Hospital, Olomouc, Czech Republic.

Department of Hemato-Oncology, Faculty of Medicine and Dentistry, Palacky University and University Hospital, Olomouc, Czech Republic.

出版信息

Br J Haematol. 2020 May;189(4):e122-e125. doi: 10.1111/bjh.16547. Epub 2020 Mar 4.

DOI:10.1111/bjh.16547
PMID:32130732
Abstract
摘要

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Ultradeep, targeted sequencing reveals distinct mutations in blood compared to matched bone marrow among patients with multiple myeloma.超深度靶向测序显示，与多发性骨髓瘤患者配对的骨髓相比，其血液中存在不同的突变。
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N-ras and p53 gene mutations are very rare events in multiple myeloma.N-ras和p53基因突变在多发性骨髓瘤中是非常罕见的事件。
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Bone marrow morphologic features, MyPRS, and gene mutation correlations in plasma cell myeloma.浆细胞骨髓瘤中的骨髓形态特征、MyPRS 和基因突变相关性。
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Rare occurrence of P53 gene mutations in multiple myeloma.多发性骨髓瘤中P53基因突变的罕见发生情况。
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引用本文的文献

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Front Oncol. 2022 May 26;12:899272. doi: 10.3389/fonc.2022.899272. eCollection 2022.
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Metabolic Disorders in Multiple Myeloma.多发性骨髓瘤的代谢紊乱。
Int J Mol Sci. 2021 Oct 22;22(21):11430. doi: 10.3390/ijms222111430.
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Whole-genome optical mapping of bone-marrow myeloma cells reveals association of extramedullary multiple myeloma with chromosome 1 abnormalities.
全基因组光学图谱骨髓浆细胞揭示骨髓外多发性骨髓瘤与 1 号染色体异常相关。
Sci Rep. 2021 Jul 19;11(1):14671. doi: 10.1038/s41598-021-93835-z.
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Metabolic Reprogramming Induces Immune Cell Dysfunction in the Tumor Microenvironment of Multiple Myeloma.代谢重编程在多发性骨髓瘤肿瘤微环境中诱导免疫细胞功能障碍。
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A Tangle of Genomic Aberrations Drives Multiple Myeloma and Correlates with Clinical Aggressiveness of the Disease: A Comprehensive Review from a Biological Perspective to Clinical Trial Results.基因组异常的纠结导致多发性骨髓瘤，并与疾病的临床侵袭性相关：从生物学角度到临床试验结果的全面综述。
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