APC Microbiome Ireland, University College Cork, Cork, Ireland.
APC Microbiome Ireland, University College Cork, Cork, Ireland; School of Microbiology, University College Cork, Cork, Ireland.
Cell Metab. 2020 Mar 3;31(3):448-471. doi: 10.1016/j.cmet.2020.02.008.
The microbiota-gut-brain axis encompasses a bidirectional mode of communication between the microorganisms residing in our gut, and our brain function and behavior. The composition of the gut microbiota is subject to diurnal variation and is entrained by host circadian rhythms. In turn, a diverse microbiota is essential for optimal regulation of host circadian pathways. Disruption of the cyclical nature of this microbe-host interaction profoundly influences disease pathology and severity. This review aims to summarize current knowledge on this bidirectional relationship. Indeed, the past few years have revealed promising data regarding the relationship between the microbiota-gut-brain axis and circadian rhythms and how they act in concert to influence disease, but further research needs to be done to examine how they coalesce to modulate severity of, and risk for, certain diseases. Moreover, there is a need for a greater understanding of the molecular mechanisms underlying the close relationship between circadian-microbiome-brain interactions.
肠道菌群-肠-脑轴包含了寄居在我们肠道中的微生物与我们的大脑功能和行为之间的双向交流模式。肠道微生物组的组成受到昼夜变化的影响，并受宿主昼夜节律的调节。反过来，多样化的微生物组对于宿主昼夜节律途径的最佳调节至关重要。这种微生物-宿主相互作用的周期性被破坏会深刻影响疾病的病理和严重程度。本综述旨在总结目前关于这种双向关系的知识。事实上，过去几年已经揭示了关于肠道菌群-肠-脑轴与昼夜节律之间关系的有希望的数据，以及它们如何协同作用来影响疾病，但需要进一步的研究来检查它们如何融合来调节某些疾病的严重程度和风险。此外，需要更好地理解昼夜节律-微生物组-大脑相互作用之间密切关系的分子机制。
