Paul T, Luhmer I, Kallfelz H C
Kinderklinik der Medizinischen Hochschule Hannover.
Z Kardiol. 1988 Jun;77(6):346-51.
34 percutaneous balloon valvuloplasties (BVP), including four repeat procedures, were performed in 30 patients (aged 3 months to 19.4 years, mean 5.8 years) with congenital pulmonary valve stenosis. Out of six failures four were due to dysplastic thickened valves; in two children a significant part of obstruction was on the subvalvular level. After first BVP a significant reduction of the right ventricular outflow tract (RVOT) gradient (mean 58.8 +/- 13.2%) was achieved in 24 of 30 cases. The mean pre-BVP RVOT gradient of 67 +/- 24.4 mm Hg was reduced to 27.2 +/- 10.2 mm Hg. Of 24 patients, 14 had a residual RVOT gradient of 25 mm Hg or less. Of the 24 patients, nine were recatheterized 12 to 24 months later, and a further RVOT gradient reduction (33.4 +/- 9.9 mm Hg to 24.2 +/- 14.5 mm Hg) was observed. In four patients additional RVOT gradient reduction (37.3 +/- 11.6 mm Hg to 18.5 +/- 10.5 mm Hg) was achieved by repeat BVP. Balloon size exceeded valve annulus diameter by up to 58% (mean 22%). No definite correlation between balloon size related to pulmonary valve annulus diameter and magnitude of right ventricular systolic pressure reduction was observed. Even using a maximal balloon size of 158%, no significant complications were noted, not even pulmonary valve insufficiency.
对30例(年龄3个月至19.4岁,平均5.8岁)先天性肺动脉瓣狭窄患者进行了34次经皮球囊瓣膜成形术(BVP),其中包括4次重复手术。6例手术失败中,4例是由于瓣膜发育异常增厚;2例儿童的梗阻主要位于瓣膜下水平。首次BVP后,30例中有24例右心室流出道(RVOT)梯度显著降低(平均58.8±13.2%)。BVP前RVOT平均梯度为67±24.4 mmHg,降至27.2±10.2 mmHg。24例患者中,14例的RVOT残余梯度为25 mmHg或更低。24例患者中,9例在12至24个月后再次进行心导管检查,观察到RVOT梯度进一步降低(从33.4±9.9 mmHg降至24.2±14.5 mmHg)。4例患者通过重复BVP实现了RVOT梯度的额外降低(从37.3±11.6 mmHg降至18.5±10.5 mmHg)。球囊尺寸比瓣膜环直径大58%(平均22%)。未观察到球囊尺寸与肺动脉瓣环直径的关系与右心室收缩压降低幅度之间存在明确相关性。即使使用最大为158%的球囊尺寸,也未发现明显并发症,甚至没有肺动脉瓣关闭不全。