Duarte Ana M, Guarino Maria P, Barroso Sónia, Gil Maria M
MARE-Marine and Environmental Sciences Center, Politécnico de Leiria, 2520-630 Peniche, Portugal.
ciTechCare-Center for Innovative Care and Health Technology, Politécnico de Leiria, 2410-541 Leiria, Portugal.
Foods. 2020 Mar 2;9(3):271. doi: 10.3390/foods9030271.
Type 2 Diabetes (T2DM) is a chronic disease which corresponds to 90% of the worldwide cases of diabetes, mainly due to epigenetic factors such as unhealthy lifestyles. First line therapeutic approaches are based on lifestyle changes, most of the time complemented with medication mostly associated with several side effects and high costs. As a result, the scientific community is constantly working for the discovery and development of natural therapeutic strategies that provide lower financial impact and minimize side effects. This review focus on these nature-based therapeutic strategies for prevention and control of T2DM, with a special emphasis on natural compounds that present pharmacological activity as dipeptidyl peptidase-4 (DPP4), alpha-amylase, alpha-glucosidase, lipase, and protein tyrosine phosphatase 1B (PTP1B) inhibitors.
2型糖尿病（T2DM）是一种慢性病，占全球糖尿病病例的90%，主要归因于不健康生活方式等表观遗传因素。一线治疗方法基于生活方式的改变，大多数情况下辅以药物治疗，但药物大多伴有多种副作用且成本高昂。因此，科学界一直在致力于发现和开发具有较低经济影响并能将副作用降至最低的天然治疗策略。本综述聚焦于这些基于天然物质的T2DM预防和控制治疗策略，特别强调具有作为二肽基肽酶-4（DPP4）、α-淀粉酶、α-葡萄糖苷酶、脂肪酶和蛋白酪氨酸磷酸酶1B（PTP1B）抑制剂的药理活性的天然化合物。
