Fadzil Mohammad Adi Mohammad, Abu Seman Norhashimah, Abd Rashed Aswir
Nutrition, Metabolism and Cardiovascular Research Centre (NMCRC), Institute for Medical Research (IMR), National Institutes of Health (NIH), Ministry of Health Malaysia (MOH), No. 1, Jalan Setia Murni U13/52, Seksyen U13 Setia Alam, Shah Alam 40170, Malaysia.
Pharmaceuticals (Basel). 2024 Nov 18;17(11):1548. doi: 10.3390/ph17111548.
In 2019, 9.3% (463 million) of adults worldwide had diabetes, according to the International Diabetes Federation (IDF). By 2030, the number will rise to 10.2% (578 million) and 10.9% (700 million) by 2045 if effective prevention methods are not implemented. Agarwood is a pathological product and valuable plant due to its numerous medicinal properties, and it is used as an essential ingredient in medicine. Therefore, we conducted this review to determine agarwood's potential health benefit effect on type 2 diabetes.
Although no clinical trials were found, the evidence from in vitro and in vivo studies is promising. Agarwood has shown the ability to reduce the activity of α-glucosidase, α-amylase, and lipase, promote adiponectin secretion during adipogenesis, and reduce oxidative stress. Animal studies elucidated hypoglycaemic, antidyslipidemia, anti-obesity, and organ protective effects from agarwood.
Original articles were searched in three databases (PubMed, Scopus, and Cochrane Library) using the medical subject heading (MeSH) term "diabetes" crossed with the term "agarwood" from 2008 to 2024. Synonyms and relevant search terms were also searched.
This effect underscores the need for further research and the potential for groundbreaking discoveries in the field of diabetes treatment.
根据国际糖尿病联盟（IDF）的数据，2019年全球9.3%（4.63亿）的成年人患有糖尿病。到2030年，如果不实施有效的预防方法，这一数字将升至10.2%（5.78亿），到2045年将达到10.9%（7亿）。沉香是一种病理产物，因其具有多种药用特性而成为珍贵植物，它被用作药物中的重要成分。因此，我们进行了这项综述，以确定沉香对2型糖尿病的潜在健康益处。
虽然未找到临床试验，但体外和体内研究的证据很有前景。沉香已显示出降低α-葡萄糖苷酶、α-淀粉酶和脂肪酶活性的能力，在脂肪生成过程中促进脂联素分泌，并减少氧化应激。动物研究阐明了沉香的降血糖、抗血脂异常、抗肥胖和器官保护作用。
使用医学主题词（MeSH）术语“糖尿病”与“沉香”交叉检索了三个数据库（PubMed、Scopus和Cochrane图书馆）中2008年至2024年的原始文章。还检索了同义词和相关检索词。
这一效应凸显了进一步研究的必要性以及糖尿病治疗领域取得突破性发现的潜力。
