School of Pharmacy, Nantong University, Nantong, People's Republic of China.
Jinghua Pharmaceutical Group Co., Ltd, Nantong, People's Republic of China.
Nat Prod Res. 2021 Nov;35(21):3766-3771. doi: 10.1080/14786419.2020.1736067. Epub 2020 Mar 5.
Two new glycosidic acids, evolvulic acids B and C ( and ), along with a known one, evolvulic acid A (), were isolated from the glycosidic acid fraction afforded by alkaline hydrolysis of crude resin glycosides from whole plants. Their structures were characterized by the spectroscopic data and chemical evidences. Compounds and are both defined as tetrasaccharides, composed of D-fucose, D-glucose, L-rhamnose or D-galactose units. Their aglycones are identified to be a distinctive 3,11,14-trihydroxyhexadecanoic acid, which is only discovered from up to now. The cytotoxic and anti-migration activities of compounds were also tested.
从全植物粗树脂糖苷经堿水解得到的糖苷酸部分分离得到两个新的糖苷酸，即进化酸 B 和 C（和），以及一个已知的进化酸 A（）。它们的结构通过光谱数据和化学证据来确定。化合物和都是由 D-岩藻糖、D-葡萄糖、L-鼠李糖或 D-半乳糖单元组成的四糖。它们的糖苷配基被鉴定为一种独特的 3,11,14-三羟基十六烷酸，迄今为止仅从中发现。还测试了化合物的细胞毒性和抗迁移活性。
