RNF126 作为胃癌预后和增殖的标志物。
RNF126 as a Marker of Prognosis and Proliferation of Gastric Cancer.
机构信息
Department of Surgery, Nara Medical University, Nara, Japan
Department of Surgery, Nara Medical University, Nara, Japan.
出版信息
Anticancer Res. 2020 Mar;40(3):1367-1374. doi: 10.21873/anticanres.14078.
BACKGROUND/AIM: Ring finger protein 126 (RNF126) belongs to the family of RING E3 ubiquitin ligases. Although RNF126 has been reported to be overexpressed in several cancers, the role of RNF126 in gastric cancer remains unclear.
MATERIALS AND METHODS
We investigated the RNF126 expression in 170 primary gastric cancer tissues by immunohistochemistry, and explored its prognostic impact. The effect of the RNF126 expression on the proliferation of cancer cells was evaluated in vitro.
RESULTS
The RNF126 expression was significantly associated with tumor depth and presence of venous invasion. The RNF126 status was identified as an independent prognostic factor (p<0.001). RNF126 gene silencing significantly inhibited the proliferation of gastric cancer cells, induced G phase arrest and increased the p21 protein level.
CONCLUSION
RNF126 expression has a significant prognostic value in gastric cancer. RNF126 may play an important role in tumor progression of gastric cancer.
背景/目的：环指蛋白 126（RNF126）属于 RING E3 泛素连接酶家族。尽管已有报道称 RNF126 在多种癌症中过表达，但 RNF126 在胃癌中的作用尚不清楚。
材料与方法
我们通过免疫组织化学法检测了 170 例原发性胃癌组织中的 RNF126 表达情况，并探讨了其预后影响。在体外评估了 RNF126 表达对癌细胞增殖的影响。
结果
RNF126 的表达与肿瘤深度和静脉侵犯显著相关。RNF126 状态被确定为独立的预后因素（p<0.001）。RNF126 基因沉默显著抑制了胃癌细胞的增殖，诱导 G1 期阻滞，并增加了 p21 蛋白水平。
结论
RNF126 表达在胃癌中有显著的预后价值。RNF126 可能在胃癌的肿瘤进展中发挥重要作用。
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