RNF126 和 BCA2 E3 泛素连接酶在 DNA 损伤修复信号转导和靶向癌症治疗中的作用。
Roles of RNF126 and BCA2 E3 ubiquitin ligases in DNA damage repair signaling and targeted cancer therapy.
机构信息
Medical Faculty of Kunming University of Science and Technology, Kunming, Yunnan, 650500, China; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China.
Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China.
出版信息
Pharmacol Res. 2020 May;155:104748. doi: 10.1016/j.phrs.2020.104748. Epub 2020 Mar 6.
The dysfunction of E3 ubiquitin ligases is important in the pathogenesis of many human diseases, as they play important roles in multiple cellular processes. In this review, we evaluated the structures, functions and clinical significance of two RING-type E3 ubiquitin ligases from the same subfamily, ring-finger protein 126 (RNF126) and breast cancer associated gene 2 (BCA2). Interestingly, the expression of RNF126 and BCA2 are regulated by multiple signaling pathways, including EGFR, ERK, AKT, and NF-κB. RNF126 and BCA2 appear to be functional mediators for not only DNA damage repair but also cancer development. Due to their significant functions in cell proliferation and DNA damage repair, RNF126 and BCA2 may be two potential diagnostic biomarkers and therapeutic targets for cancers.
E3 泛素连接酶的功能障碍在许多人类疾病的发病机制中很重要，因为它们在多种细胞过程中发挥重要作用。在这篇综述中，我们评估了两个来自同一亚家族的 RING 型 E3 泛素连接酶，即环指蛋白 126（RNF126）和乳腺癌相关基因 2（BCA2）的结构、功能和临床意义。有趣的是，RNF126 和 BCA2 的表达受多种信号通路调节，包括 EGFR、ERK、AKT 和 NF-κB。RNF126 和 BCA2 似乎不仅是 DNA 损伤修复的功能性介质，也是癌症发展的功能性介质。由于它们在细胞增殖和 DNA 损伤修复中的重要功能，RNF126 和 BCA2 可能是两种潜在的癌症诊断生物标志物和治疗靶点。
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