Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Department of Pathology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
Anticancer Res. 2020 Mar;40(3):1487-1494. doi: 10.21873/anticanres.14093.
BACKGROUND/AIM: The clinicopathological and prognostic significances of programmed death ligand 1 (PD-L1) expression in triple-negative breast carcinoma (TNBC) are still unclear. We investigated whether PD-L1 expression is associated with clinicopathological characteristics and outcomes of TNBC patients.
We performed immunostaining for PD-L1 (SP142) in 83 TNBCs. Staining proportion of ≥1% was regarded as positive PD-L1 expression.
Positive intratumoral (IT) PD-L1 expression (19/83; 22.9%) was inversely associated with lymphovascular invasion (LVI) and distant metastasis, and was significantly associated with better disease-free survival for TNBC patients. Positive stromal PD-L1 expression (44/83; 53.0%) also correlated inversely with LVI.
Positive IT PD-L1 expression was associated with favorable outcomes in TNBC. In addition, positive IT and stromal PD-L1 were inversely associated with LVI and distant metastasis of TNBC.
背景/目的：程序性死亡配体 1（PD-L1）在三阴性乳腺癌（TNBC）中的表达的临床病理和预后意义尚不清楚。我们研究了 PD-L1 表达是否与 TNBC 患者的临床病理特征和结局相关。
我们对 83 例 TNBC 进行了 PD-L1（SP142）免疫染色。将≥1%的染色比例视为 PD-L1 阳性表达。
肿瘤内（IT）PD-L1 阳性表达（19/83；22.9%）与脉管侵犯（LVI）和远处转移呈负相关，与 TNBC 患者的无病生存显著相关。阳性间质 PD-L1 表达（44/83；53.0%）也与 LVI 呈负相关。
IT 中 PD-L1 阳性表达与 TNBC 的良好结局相关。此外，IT 和间质 PD-L1 阳性与 TNBC 的 LVI 和远处转移呈负相关。
