Dyková Iva, Blažek Radim, Součková Kamila, Reichard Martin, Slabý Ondřej
Institute of Botany and Zoology, Masaryk University, Brno 60137, Czech Republic.
Dis Aquat Organ. 2020 Jan 30;137(3):205-210. doi: 10.3354/dao03437.
Nothobranchius fishes (Cyprinodontiformes), known for their genetically encoded extremely compressed lifespan, are considered an excellent vertebrate model for the research of aging. Unlike the rapid accumulation of data concerning their biology, ecology and genome, knowledge of their age-related diseases, including tumours, is still very limited. This Note reports spontaneous neoplastic lesions in the swim bladder gas glands of Nothobranchius furzeri, N. kadleci and N. orthonotus. Based on light and transmission electron microscopy, the neoplastic proliferation of gas gland cells was classified as adenocarcinoma. There was a concurrent proliferation of haemopoietic cells in the kidney interstitium in all individuals diagnosed with this type of primary neoplasia.
假鳃鳉属鱼类（鲤齿目）以其基因编码的极度压缩的寿命而闻名，被认为是研究衰老的优秀脊椎动物模型。与关于它们的生物学、生态学和基因组的数据迅速积累不同，关于它们与年龄相关的疾病，包括肿瘤的知识仍然非常有限。本报告记录了费氏假鳃鳉、卡氏假鳃鳉和直背假鳃鳉的鳔气腺中的自发性肿瘤病变。基于光学显微镜和透射电子显微镜观察，气腺细胞的肿瘤性增殖被归类为腺癌。在所有被诊断患有这种原发性肿瘤的个体中，肾间质中同时存在造血细胞增殖。
