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[癌症生存的预后因素:流行病学模型]

[Prognostic factors in survival after cancer: epidemiological model].

作者信息

Raymond L, Obradovic M, Fioretta G

机构信息

Institut de médecine sociale et préventive, Université de Genève.

出版信息

Soz Praventivmed. 1988;33(6):269-73. doi: 10.1007/BF02106781.

DOI:10.1007/BF02106781
PMID:3213241
Abstract

Quality of care assessment is one of the principal issues considered when studying the survival of cancer patients. Survival rates based on hospital series ("clinical survival") essentially aim at evaluating the impact of therapy, taking into account the stage of the tumor. When, on the other hand, survival rates refer to a demographically defined population ("epidemiologic survival") they depend not only on quality of therapy but also on differentials in access to health services which in turn condition partly the stage at time of diagnosis and therapy selection. Since these patterns of access can vary according to socio-cultural characteristics, the epidemiologist is tempted to focus the prognostic analysis of survival on these characteristics. In a cancer registry setting, clinical indicators (stage of the lesions, type of health care institution and therapy) must not be neglected. Rather, these must be analyzed both as co-factors of survival and as phenomena to be explained in their own right. Issues relating to this topic are discussed using the example of breast cancer in Geneva.

摘要

医疗质量评估是研究癌症患者生存率时考虑的主要问题之一。基于医院病例系列得出的生存率(“临床生存率”)主要旨在评估治疗的影响,同时考虑肿瘤分期。另一方面,当生存率涉及到按人口统计学定义的人群时(“流行病学生存率”),它们不仅取决于治疗质量,还取决于获得医疗服务的差异,而这又部分决定了诊断时的分期和治疗选择。由于这些获得医疗服务的模式会因社会文化特征而有所不同,流行病学家倾向于将生存预后分析聚焦于这些特征。在癌症登记处的环境中,临床指标(病变分期、医疗机构类型和治疗方法)不容忽视。相反,这些指标既必须作为生存的共同因素进行分析,也必须作为自身有待解释的现象进行分析。本文以日内瓦的乳腺癌为例讨论了与该主题相关的问题。

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1
[Prognostic factors in survival after cancer: epidemiological model].[癌症生存的预后因素:流行病学模型]
Soz Praventivmed. 1988;33(6):269-73. doi: 10.1007/BF02106781.
2
Overview of resistance to systemic therapy in patients with breast cancer.乳腺癌患者全身治疗耐药概述。
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Breast cancer family history leads to early breast cancer detection and optimal management.乳腺癌家族史有助于早期乳腺癌检测和优化治疗。
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Long-term inequalities in breast cancer survival--a ten year follow-up study of patients managed within a National Health Care System (Sweden).乳腺癌生存的长期不平等——对瑞典国家医疗保健系统内接受治疗的患者进行的十年随访研究
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Socioeconomic variation in cancer survival in the southeastern Netherlands, 1980-1989.1980 - 1989年荷兰东南部癌症生存率的社会经济差异
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Breast cancer prognosis is inherited independently of patient, tumor and treatment characteristics.乳腺癌预后独立于患者、肿瘤和治疗特征。
Int J Cancer. 2012 May 1;130(9):2103-10. doi: 10.1002/ijc.26206. Epub 2011 Nov 17.

本文引用的文献

1
Survival of cancer patients in Finland in 1953-1974.
Ann Clin Res. 1981;13 Suppl 31:1-101.
2
Race and socio-economic status in survival from breast cancer.乳腺癌生存中的种族与社会经济地位
J Chronic Dis. 1982;35(8):675-83. doi: 10.1016/0021-9681(82)90020-0.
3
Economic differentials in cancer survival: a multivariate analysis.癌症生存率的经济差异:一项多变量分析。
J Chronic Dis. 1984;37(3):183-93. doi: 10.1016/0021-9681(84)90146-2.
4
Survival of cancer patients by economic status in a free care setting.在免费医疗环境下按经济状况划分的癌症患者生存率
Cancer. 1985 Apr 1;55(7):1552-5. doi: 10.1002/1097-0142(19850401)55:7<1552::aid-cncr2820550723>3.0.co;2-e.
5
The effect of marital status on stage, treatment, and survival of cancer patients.婚姻状况对癌症患者分期、治疗及生存的影响。
JAMA. 1987 Dec 4;258(21):3125-30.
6
Cancers of affluence: positive social class gradient and rising incidence trend in some cancer forms.富贵病:社会阶层呈正向梯度以及某些癌症发病率呈上升趋势。
Soc Sci Med. 1987;24(7):601-6. doi: 10.1016/0277-9536(87)90064-5.
7
Cancer survival and social class in Sweden.瑞典的癌症生存率与社会阶层
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Economic status and survival of cancer patients.癌症患者的经济状况与生存情况
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