Papanikolaou Dimitra, Savio Chris, Zafar Mohammad A, Freudzon Leon, Wu Jinlin, Abdelbaky Mohamed, Pelletier Keith J, Buntin Joelle, Faggion Vinholo Thais, Ziganshin Bulat A, Schwartz Brian, Elefteriades John A
Aortic Institute at Yale-New Haven Hospital, Yale University School of Medicine, New Haven, Connecticut.
Department of Surgical Diseases, Kazan State Medical University, Kazan, Russia.
Int J Angiol. 2020 Mar;29(1):19-26. doi: 10.1055/s-0039-3400479. Epub 2019 Dec 9.
Left atrial-femoral artery (LA-FA) bypass with a centrifugal pump and no oxygenator is commonly used for descending and thoracoabdominal aortic (DTAA) operations, mitigating the deleterious effects of cross-clamping. We present our initial experience performing DTAA replacement under LA-FA (left-to-left) cardiopulmonary bypass (CPB) with an oxygenator. DTAA replacement under LA-FA bypass with an oxygenator was performed in 14 consecutive patients (CPB group). The pulmonary vein and femoral artery (or distal aorta) were cannulated and the full CPB machine were used, including oxygenator, roller pump, pump suckers, and kinetically enhanced drainage. The CPB group was compared with 50 consecutive patients who underwent DTAA replacement utilizing traditional LA-FA bypass without an oxygenator (LA-FA group). Perioperative data were collected and statistical analyses were performed. All CPB patients maintained superb cardiopulmonary stability. The pump sucker permitted immediate salvage and return of shed blood. Superb oxygenation was maintained at all times. High-dose full CPB heparin was reversed without difficulty. The CPB group required markedly fewer blood transfusions than the LA-FA group (2.21 vs. 5.88 units, < 0.004). The 30-day mortality rate was 7.1% ( = 1) and there were no paraplegia cases in the CPB group versus 7 (14%) deaths and 3 (6%) paraplegia cases in the LA-FA group. Traditional LA-FA bypass without an oxygenator avoids high-dose heparin. In the present era, heparin reversal is more secure. Our experience finds that the novel application of LA-FA CPB with an oxygenator is safe and suggests improved hemodynamics (immediate return of shed blood) and a hemostatic advantage (avoidance of loss of coagulation factors in the cell saver).
使用离心泵且无氧合器的左心房 - 股动脉(LA - FA)旁路常用于降主动脉和胸腹主动脉(DTAA)手术,以减轻交叉钳夹的有害影响。我们介绍了在使用氧合器的LA - FA(左到左)体外循环(CPB)下进行DTAA置换的初步经验。在14例连续患者中进行了使用氧合器的LA - FA旁路下的DTAA置换(CPB组)。将肺静脉和股动脉(或远端主动脉)插管,并使用完整的CPB机器,包括氧合器、滚压泵、泵吸器和动态增强引流。将CPB组与50例连续接受使用无氧合器的传统LA - FA旁路进行DTAA置换的患者(LA - FA组)进行比较。收集围手术期数据并进行统计分析。所有CPB患者均保持了出色的心肺稳定性。泵吸器允许立即回收和回输失血。始终保持良好的氧合。高剂量的全CPB肝素逆转没有困难。CPB组所需的输血明显少于LA - FA组(2.21单位对5.88单位, < 0.004)。CPB组的30天死亡率为7.1%( = 1),且无截瘫病例,而LA - FA组有7例(14%)死亡和3例(6%)截瘫病例。不使用氧合器的传统LA - FA旁路可避免高剂量肝素。在当今时代,肝素逆转更安全。我们的经验发现,使用氧合器的LA - FA CPB的新应用是安全的,并提示改善了血流动力学(失血立即回输)和止血优势(避免细胞回收器中凝血因子的损失)。