Coselli Joseph S, LeMaire Scott A, Conklin Lori D, Adams Gerald J
The Michael E. DeBakey Department of Surgery, Division of Cardiothoracic Surgery, Baylor College of Medicine and The Methodist DeBakey Heart Center, Houston, Texas, USA.
Ann Thorac Surg. 2004 Apr;77(4):1298-303; discussion 1303. doi: 10.1016/j.athoracsur.2003.10.033.
The preferred technique for spinal cord protection during surgical repair of descending thoracic aortic aneurysms (DTAAs) remains controversial. The purpose of this retrospective analysis was to determine if the use of left heart bypass (LHB) reduced the incidence of paraplegia in patients who underwent DTAA repair.
Over a 15-year period 387 consecutive patients underwent surgical repair of DTAAs using either the "clamp-and-sew" technique (341 patients, 88.1%) or distal aortic perfusion via a LHB circuit (46 patients, 11.9%). Data regarding patient characteristics, operative variables, and outcomes were retrieved from a prospectively maintained database. The impact of LHB on the frequency of paraplegia was determined using univariate and propensity score analyses.
There were 17 operative deaths (4.4%) including 11 patients (2.8%) who died within 30 days. Paraplegia occurred in 10 patients (2.6%). On univariate analysis increasing age (p = 0.03), increasing aortic clamp time (p < 0.001), increasing red blood cell transfusion requirements (p = 0.01), and acute dissection (p = 0.03) were associated with increased incidence of paraplegia. Patients who received LHB had a similar incidence of paraplegia (2/46, 4%) compared with those treated without LHB (8/341, 2.3%; p = 0.3). Both matching and stratification propensity score analyses confirmed that LHB was not associated with reduced risk of paraplegia.
On retrospective analysis the use of LHB during DTAA repair did not reduce the incidence of spinal cord injury. The "clamp-and-sew" technique remains an appropriate approach to DTAA repair.
在降主动脉瘤(DTAA)手术修复过程中,脊髓保护的首选技术仍存在争议。本回顾性分析的目的是确定使用左心转流(LHB)是否能降低接受DTAA修复患者的截瘫发生率。
在15年期间,387例连续患者接受了DTAA手术修复,采用“钳夹缝合”技术(341例患者,88.1%)或通过LHB回路进行远端主动脉灌注(46例患者,11.9%)。从一个前瞻性维护的数据库中检索有关患者特征、手术变量和结果的数据。使用单因素分析和倾向评分分析确定LHB对截瘫发生率的影响。
有17例手术死亡(4.4%),包括11例(2.8%)在30天内死亡的患者。10例患者(2.6%)发生截瘫。单因素分析显示,年龄增加(p = 0.03)、主动脉阻断时间增加(p < 0.001)以及红细胞输注需求增加(p = 0.01)和急性夹层(p = 0.03)与截瘫发生率增加相关。接受LHB的患者截瘫发生率(2/46,4%)与未接受LHB治疗的患者(8/341,2.3%;p = 0.3)相似。匹配和分层倾向评分分析均证实,LHB与降低截瘫风险无关。
回顾性分析表明,在DTAA修复过程中使用LHB并不能降低脊髓损伤的发生率。“钳夹缝合”技术仍然是DTAA修复的合适方法。