Yao Xinwen, Li Dawei, Park Hyeon-Cheol, Chen Defu, Guan Honghua, Mahendroo Mala, Li Xingde
Department of Biomedical Engineering, 720 Rutland Ave, Baltimore, MD 21205, USA.
SERI-NTU Advanced Ocular Engineering (STANCE), 50 Nanyang Drive #04-13, Singapore 637553, Singapore.
Biomed Opt Express. 2020 Jan 9;11(2):688-698. doi: 10.1364/BOE.383720. eCollection 2020 Feb 1.
An ultra-sensitive, wide-range force loading scheme is proposed for compression optical coherence elastography (OCE) that allows for the quantitative analysis of cervical tissue elasticity . We designed a force loading apparatus featuring a water sink for minuscule incremental loading through a volume-controlled water droplet, from which the Young's modulus can be calculated by fitting the stress-strain curve. We validated the performance of the proposed OCE system on homogenous agar phantoms, showing the Young's modulus can be accurately estimated using this scheme. We then measured the Young's modulus of rodent cervical tissues acquired at different gestational ages, showing that the cervical rigidity of rodents was significantly dropped when entering the third trimester of pregnancy.
我们提出了一种用于压缩光学相干弹性成像（OCE）的超灵敏、宽范围力加载方案，该方案可对宫颈组织弹性进行定量分析。我们设计了一种力加载装置，其具有一个水槽，用于通过体积控制的水滴进行微小增量加载，通过拟合应力-应变曲线可从中计算出杨氏模量。我们在均匀的琼脂模型上验证了所提出的OCE系统的性能，结果表明使用该方案可以准确估计杨氏模量。然后，我们测量了在不同胎龄获取的啮齿动物宫颈组织的杨氏模量，结果表明啮齿动物进入妊娠晚期时宫颈硬度显著下降。
