急性心肌梗死患者高尿酸血症的发病率——一项病例对照研究
Incidence of Hyperuricemia in Patients with Acute Myocardial Infarction - A Case-Control Study.
作者信息
Mal Kheraj, Jabar Ali Jamila Begum, Fatima Kiran, Rizwan Amber
机构信息
Cardiology, National Institute of Cardiovascular Diseases, Sukkur, PAK.
Internal Medicine, Rajiv Gandhi University of Health Sciences, Chitradurga, IND.
出版信息
Cureus. 2020 Jan 21;12(1):e6722. doi: 10.7759/cureus.6722.
Introduction Various researches have stated the correlation between serum uric acid (sUA) and cardiovascular disease (CVD); however, no local studies are available. In this study, we will determine the prevalence of hyperuricemia in patients with acute myocardial infarction and compare with the control group. Methods This case-control study was conducted from March to November 2019 in the tertiary care hospital in Pakistan. In all, 119 patients with acute myocardial infarction were enrolled in this study, and 119 controls were identified from the outpatient department. Their sUA levels were measured within 24 hours of acute myocardial infarction. Results The mean sUA levels were significantly higher in patients with acute myocardial infarction (AMI) in comparison to the control group (6.17 ± 2.12 vs. 5.51 ± 1.89, -value; 0.01). Overall, there were more patients with hyperuricemia in the case group compared to the control group (47.89% vs. 33.6%, -value = 0.04) Conclusion In this study, after adjustment of other known factors, hyperuricemia is associated with AMI. Efforts should be made to include screening for hyperuricemia in patients with a high risk of myocardial infarction.
引言 各种研究都阐述了血清尿酸（sUA）与心血管疾病（CVD）之间的相关性；然而，尚无本地研究。在本研究中，我们将确定急性心肌梗死患者中高尿酸血症的患病率，并与对照组进行比较。方法 本病例对照研究于2019年3月至11月在巴基斯坦的一家三级护理医院进行。总共119例急性心肌梗死患者纳入本研究，119名对照从门诊患者中确定。在急性心肌梗死24小时内测量他们的sUA水平。结果 与对照组相比，急性心肌梗死（AMI）患者的平均sUA水平显著更高（6.17±2.12对5.51±1.89，P值；0.01）。总体而言，病例组中高尿酸血症患者比对照组更多（47.89%对33.6%，P值=0.04） 结论 在本研究中，在调整其他已知因素后，高尿酸血症与AMI相关。应努力将心肌梗死高危患者的高尿酸血症筛查纳入其中。
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