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纵隔冬眠瘤:慢性咳嗽的罕见病因

Mediastinal Hibernoma: A Rare Cause of Chronic Cough.

作者信息

Muñoz-Palacio Bernardo J, Figueroa Shairine, Matute Gustavo, Garcia-Mejía Carolina, Betancur Juan F

机构信息

Pulmonology, Clinica Medellin, Medellin, COL.

Internal Medicine, Clinica Las Américas, Medellin, COL.

出版信息

Cureus. 2020 Jan 22;12(1):e6738. doi: 10.7759/cureus.6738.

DOI:10.7759/cureus.6738
PMID:32133260
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7034743/
Abstract

A hibernoma is an uncommon benign soft tissue tumor composed of brown adipose cells; the mediastinal location as presentation is scarce, with only six cases previously reported. The diagnosis of hibernoma is challenging and must be made based on the clinical, radiographic, and cytologic features. Here we present a 33-year-old woman without any relevant medical history presented for outpatient evaluation of a dry cough persisting for three months, and the X-rays revealed a dense well-defined mass with smooth borders in the left upper posterior mediastinum.  Posterior mediastinal lesions represent a relatively small proportion of patient loads in thoracic surgery and account for a total of 25% of the cases, with neurogenic tumors among the most frequently seen in adults. Of these, the nerve sheath tumors (schwannoma, neurofibroma, paraspinal ganglioneuroma) are the most seen. Other differential diagnoses of paravertebral masses are the paraspinal abscess, metastases, hematoma, descending aortic aneurysm, among others. The patient underwent surgical resection via left posterolateral thoracotomy, without complications.

摘要

冬眠瘤是一种由棕色脂肪细胞组成的罕见良性软组织肿瘤;以纵隔部位为表现的情况很少见,此前仅报道过6例。冬眠瘤的诊断具有挑战性,必须根据临床、影像学和细胞学特征来做出诊断。在此,我们报告一名33岁女性,无任何相关病史,因持续三个月的干咳前来门诊评估,X线检查显示左上后纵隔有一个边界清晰、密度较高且边缘光滑的肿块。后纵隔病变在胸外科患者中所占比例相对较小,占病例总数的25%,其中神经源性肿瘤在成人中最为常见。其中,神经鞘瘤(神经鞘瘤、神经纤维瘤、椎旁神经节瘤)最为多见。椎旁肿块的其他鉴别诊断包括椎旁脓肿、转移瘤、血肿、降主动脉瘤等。患者通过左后外侧开胸手术进行了切除,无并发症发生。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e241/7034743/7976b1b1e2d7/cureus-0012-00000006738-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e241/7034743/13849f8a7adc/cureus-0012-00000006738-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e241/7034743/e8665c04c4b0/cureus-0012-00000006738-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e241/7034743/7976b1b1e2d7/cureus-0012-00000006738-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e241/7034743/13849f8a7adc/cureus-0012-00000006738-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e241/7034743/e8665c04c4b0/cureus-0012-00000006738-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e241/7034743/7976b1b1e2d7/cureus-0012-00000006738-i03.jpg

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本文引用的文献

1
Mediastinal Hibernoma: A Rare Case with Radiologic-Pathologic Correlation.纵隔冬眠瘤:一例罕见的影像学与病理学对照病例
Case Rep Radiol. 2016;2016:2378143. doi: 10.1155/2016/2378143. Epub 2016 Aug 29.
2
Deep-seated huge hibernoma of soft tissue: a rare differential diagnosis of atypical lipomatous tumor/well differentiated liposarcoma.深部软组织巨大冬眠瘤:非典型脂肪瘤性肿瘤/高分化脂肪肉瘤的一种罕见鉴别诊断。
Int J Clin Exp Pathol. 2013 Sep 15;6(10):2178-84. eCollection 2013.
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Symptomatic hibernoma: a rare soft tissue tumor.症状性冬眠瘤:一种罕见的软组织肿瘤。
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Imaging of hibernomas: A retrospective study on twelve cases.冬眠瘤的影像学表现:一项针对12例病例的回顾性研究。
Clin Sarcoma Res. 2011 Jul 25;1(1):3. doi: 10.1186/2045-3329-1-3.
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Hibernomas: clinicopathological features, diagnosis, and treatment of 17 cases.冬眠瘤:17例临床病理特征、诊断及治疗
Orthopedics. 2011 Nov 9;34(11):e755-9. doi: 10.3928/01477447-20110922-12.
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Mediastinal hibernoma presenting with hoarseness.表现为声音嘶哑的纵隔冬眠瘤。
Interact Cardiovasc Thorac Surg. 2011 May;12(5):845-6. doi: 10.1510/icvts.2010.256750. Epub 2011 Feb 5.
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Concomitant deletions of tumor suppressor genes MEN1 and AIP are essential for the pathogenesis of the brown fat tumor hibernoma.抑癌基因 MEN1 和 AIP 的同时缺失对于棕色脂肪肿瘤冬眠瘤的发病机制至关重要。
Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):21122-7. doi: 10.1073/pnas.1013512107. Epub 2010 Nov 15.
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Identification and importance of brown adipose tissue in adult humans.成人棕色脂肪组织的识别及其重要性。
N Engl J Med. 2009 Apr 9;360(15):1509-17. doi: 10.1056/NEJMoa0810780.
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CT and MR characteristics of hibernoma: six cases.冬眠瘤的CT和MR特征:6例报告
Clin Imaging. 2008 Jan-Feb;32(1):42-7. doi: 10.1016/j.clinimag.2007.07.001.
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Hibernoma: MRI features in eight consecutive cases.冬眠瘤:连续8例的MRI特征
Clin Radiol. 2006 Dec;61(12):1029-34. doi: 10.1016/j.crad.2006.05.018.