Department of Prosthodontics, Qingdao Stomatology Hospital, Qingdao, Shandong, China.
Kaohsiung J Med Sci. 2020 Jul;36(7):483-493. doi: 10.1002/kjm2.12201. Epub 2020 Mar 5.
Recent investigations have suggested that microRNA-129-5p (miR-129-5p) is commonly dysregulated in multiple types of malignancies. Nevertheless, the roles of miR-129-5p in human oral squamous cell carcinoma (OSCC) are not well explored. Herein, we demonstrated that miR-129-5p was down-expressed in OSCC cells and tissues. Moreover, miR-129-5p overexpression restrained the growth, migration ability, and invasiveness of OSCC cells. Notably, high-mobility group box 1 protein (HMGB1) was identified as a downstream target of miR-129-5p. Additional, knockdown of HMGB1 suppressed the growth and aggressive phenotypes of human OSCC cells. Importantly, re-expression of HMGB1 impaired the inhibitory impacts of miR-129-5p on the metastasis of OSCC cells. Altogether, these results implied that miR-129-5p restrained the aggressiveness of OSCC cells through modulating HMGB1.
最近的研究表明，微小 RNA-129-5p（miR-129-5p）在多种恶性肿瘤中普遍失调。然而，miR-129-5p 在人口腔鳞状细胞癌（OSCC）中的作用尚未得到充分探索。在此，我们证明 miR-129-5p 在 OSCC 细胞和组织中表达下调。此外，miR-129-5p 的过表达抑制了 OSCC 细胞的生长、迁移能力和侵袭性。值得注意的是，高迁移率族蛋白 B1（HMGB1）被鉴定为 miR-129-5p 的下游靶标。此外，HMGB1 的敲低抑制了人 OSCC 细胞的生长和侵袭表型。重要的是，HMGB1 的重新表达削弱了 miR-129-5p 对 OSCC 细胞转移的抑制作用。总之，这些结果表明，miR-129-5p 通过调节 HMGB1 抑制 OSCC 细胞的侵袭性。
