豚鼠胸腺来源淋巴细胞与兔红细胞之间非免疫性玫瑰花结形成的机制。

Mechanism of formation of non-immune rosettes between guinea-pig thymus-derived lymphocytes and rabbit erythrocytes.

作者信息

Godfrey H P

出版信息

Immunology. 1977 Jan;32(1):25-31.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1445194/

Abstract

Several observations reported here suggest that spontaneous rosette formation between rabbit erythrocytes and guinea-pig T lymphocytes is mediated by natural anti-guinea-pig T-cell antibodies bound to the surface of the rabbit erythrocyte. First, normal rabbit sera frequently contain antibodies specifically cytotoxic for guinea-pig T lymphocytes. Second, the activity of rabbit erythrocytes in spontaneous rosette formation is reduced after incubation for 5 days at pH 6-1, but can be restored to levels seen with fresh erythrocytes by a brief incubation in normal rabbit serum containing natural anti-guinea-pig antibodies; normal serum absorbed with thymocytes does not restore activity to the erythrocytes. Third, the activity of rabbit erythrocytes in forming spontaneous rosettes can be specifically blocked by treatment with anti-allotype and heterologous anti-Ig sera.

摘要

本文报道的几项观察结果表明，兔红细胞与豚鼠T淋巴细胞之间的自发玫瑰花结形成是由结合在兔红细胞表面的天然抗豚鼠T细胞抗体介导的。首先，正常兔血清中经常含有对豚鼠T淋巴细胞具有特异性细胞毒性的抗体。其次，兔红细胞在pH 6-1下孵育5天后，其在自发玫瑰花结形成中的活性降低，但通过在含有天然抗豚鼠抗体的正常兔血清中短暂孵育，可恢复到新鲜红细胞的水平；用胸腺细胞吸收的正常血清不能使红细胞恢复活性。第三，用抗同种异型和异源抗Ig血清处理可特异性阻断兔红细胞形成自发玫瑰花结的活性。

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本文引用的文献

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THE PHYSIOLOGICAL ROLE OF THE LYMPHOID SYSTEM, II. ERYTHROPHILIC gamma-GLOBULIN AND THE SURVIVAL OF THE ERYTHROCYTE.淋巴系统的生理作用，II. 嗜红细胞γ球蛋白与红细胞的存活

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Immunoglobulin allotypes of experimental animals.实验动物的免疫球蛋白同种异型

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Receptors for complement and immunoglobulin on human and animal lymphoid cells.人和动物淋巴样细胞上的补体及免疫球蛋白受体

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Rosette formation by guinea pig thymocytes and thymus derived lymphocytes with rabbit red blood cells.豚鼠胸腺细胞和胸腺衍生淋巴细胞与兔红细胞形成玫瑰花结。

J Immunol. 1973 Dec;111(6):1834-7.

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The physiological role of the lymphoid system. V. The binding of autologous (erythrophilic) gamma globulin to human red blood cells.

Biochemistry. 1967 Nov;6(11):3378-85. doi: 10.1021/bi00863a007.

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Populations of guinea pig lymphocytes and Kurloff cells characterised by rosette-forming reactions.以玫瑰花结形成反应为特征的豚鼠淋巴细胞和库尔洛夫细胞群体。

Int Arch Allergy Appl Immunol. 1974;47(6):850-63. doi: 10.1159/000231276.

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Rosette-formation between guinea pig lymphoid cells and rabbit erythrocytes--a possible T-cell marker.豚鼠淋巴细胞与兔红细胞之间的玫瑰花结形成——一种可能的T细胞标志物。

Int Arch Allergy Appl Immunol. 1973;44(4):544-52. doi: 10.1159/000230959.

8

Surface markers on human T and B lymphocytes. I. A large population of lymphocytes forming nonimmune rosettes with sheep red blood cells.人类T和B淋巴细胞的表面标志物。I. 大量与绵羊红细胞形成非免疫性玫瑰花结的淋巴细胞。

J Exp Med. 1972 Aug 1;136(2):207-15. doi: 10.1084/jem.136.2.207.

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Surface antigenic markers for distinguishing T and B lymphocytes in mice.用于区分小鼠T淋巴细胞和B淋巴细胞的表面抗原标志物。

Transplant Rev. 1971;6:52-80. doi: 10.1111/j.1600-065x.1971.tb00459.x.

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Lymphocyte: erythrocyte (L.E.) rosettes as indicators of the heterogeneity of lymphocytes in a variety of mammalian species.

Cell. 1975 Feb;4(2):103-6. doi: 10.1016/0092-8674(75)90115-4.

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