Misra S, Sakhuja P, Agarwal A K, Javed A
Department of Pathology, GB Pant Institute of Post Graduate Medical Education and Research, New Delhi, India.
Department of Gastrointestinal Surgery, GB Pant Institute of Post Graduate Medical Education and Research, New Delhi, India.
J Postgrad Med. 2020 Apr-Jun;66(2):99-101. doi: 10.4103/jpgm.JPGM_605_19.
Amebiasis caused by protozoa Entamoeba histolytica (EH) is the third leading parasitic cause of human mortality. Although amebiasis is endemic in India, only about 10% of the infected individuals manifest disease. Clinical spectrum of amebiasis ranges from asymptomatic colonization to amebic colitis to hemorrhagic and fulminant colitis. Factors causing an invasive infection are not completely understood. Pathogen virulence, host immunity, and ability of the pathogen to evade host immune response play vital role in determining the disease course. Host factors such as immunocompromised states may make an individual susceptible to develop symptomatic infection. Malignancies usually result in chronic debilitation which may make the individual prone to develop invasive amebiasis with rapid progression. We report two cases of invasive amebiasis which developed a fulminant course in the immediate postoperative period after abdominal surgeries for visceral malignancies.
由原生动物溶组织内阿米巴（EH）引起的阿米巴病是人类死亡的第三大主要寄生虫病因。尽管阿米巴病在印度呈地方性流行，但只有约10%的感染者会出现疾病症状。阿米巴病的临床谱包括无症状定植、阿米巴结肠炎、出血性和暴发性结肠炎。导致侵袭性感染的因素尚未完全明确。病原体毒力、宿主免疫力以及病原体逃避宿主免疫反应的能力在决定疾病进程中起着至关重要的作用。宿主因素如免疫功能低下状态可能使个体易发生有症状感染。恶性肿瘤通常导致慢性衰弱，这可能使个体易于发生侵袭性阿米巴病且病情进展迅速。我们报告了两例侵袭性阿米巴病病例，这两例患者在内脏恶性肿瘤腹部手术后的即刻术后期间病情发展为暴发性。
