Visible-Light-Induced Monofluoroalkenylation and -Difluoroallylation of Inactivated C(sp)-H Bonds via 1,5-Hydrogen Atom Transfer (HAT).

The direct monofluoroalkenylation of C(sp)-H bonds is of great importance and quite challenging. Current methods have been restricted to the monofluoroalkenylation of activated C(sp)-H bonds. Here, we reported the photocatalyzed C(sp)-H monofluoroalkenylation of inactivated C(sp)-H bonds with -difluoroalkenes via 1,5-hydrogen atom transfer. This process shows good functional group tolerance, such as halides (F, Cl), nitrile, sulfone, ester, and pyridine, and good γ-selectivity. Moreover, this method succeeds in the photocatalyzed -difluoroallylation of inactivated C(sp)-H with α-trifluoromethyl alkenes.