National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Ropewalk House, Nottingham, UK.
Hearing Sciences, Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, UK.
Int J Audiol. 2020 Aug;59(8):640-646. doi: 10.1080/14992027.2020.1733677. Epub 2020 Mar 5.
To develop an innovative prioritisation process to identify topics for new or updated systematic reviews of tinnitus research. A two-stage prioritisation process was devised. First, a scoping review assessed the amount of randomized controlled trial-level evidence available. This enabled development of selection criteria for future reviews, aided the design of template protocol and suggested the scale of work that would be required to conduct these reviews. Second, using the pre-defined primary and secondary criteria, interventions were prioritised for systematic review.Study sample: Searches identified 1080 records. After removal of duplicates and out of scope works, 437 records remained for full data charting. The process was tested, using subjective tinnitus as the clinical condition and using Cochrane as the systematic review platform. The criteria produced by this process identified three high priority reviews: (1) Sound therapy using amplification devices and/or sound generators; (2) Betahistine and (3) Cognitive behaviour therapy. Further secondary priorities were: (4) Gingko biloba, (5) Anxiolytics, (6) Hypnotics, (7) Antiepileptics and (8) Neuromodulation. A process was developed which successfully identified priority areas for Cochrane systematic reviews of interventions for subjective tinnitus. This technique could easily be transferred to other conditions and other types of systematic reviews.
为了开发一种创新的优先级确定过程，以确定耳鸣研究新的或更新的系统评价主题。设计了一个两阶段的优先级确定过程。首先，进行了范围审查，评估了随机对照试验水平证据的数量。这使我们能够为未来的综述制定选择标准，辅助模板方案的设计，并提示进行这些综述所需的工作规模。其次，使用预先定义的主要和次要标准，对干预措施进行系统评价的优先级排序。
搜索确定了 1080 条记录。去除重复项和不相关的作品后，剩余 437 条记录用于完整的数据图表。该过程经过了测试，以主观耳鸣作为临床条件，并使用 Cochrane 作为系统评价平台。该过程产生的标准确定了三个高优先级的综述：（1）使用放大设备和/或声音发生器的声音疗法；（2）倍他司汀；（3）认知行为疗法。进一步的次要优先级为：（4）银杏叶，（5）抗焦虑药，（6）催眠药，（7）抗癫痫药和（8）神经调节。开发了一种成功确定主观耳鸣干预措施的 Cochrane 系统评价优先领域的方法。这种技术可以很容易地应用于其他条件和其他类型的系统评价。
