de Waal Malefijt J, Slooff T J, Huiskes R, de Laat E A, Barentsz J O
Laboratory for Experimental Orthopedics, University of Nijmegen, The Netherlands.
Acta Orthop Scand. 1988 Dec;59(6):643-9. doi: 10.3109/17453678809149416.
We studied two groups of 6 adult female African pygmy goats, which received cemented or uncemented femoral endoprostheses in their right hip. One additional goat was used for in vivo angiography preoperatively and postoperatively. The blood supply to the proximal femur at a macroscopic level was not severed by the operation. Until the 6th postoperative week, the animals were killed at weekly intervals. Microangiography and fluorescence microscopy revealed that rapid revascularization of the metaphyseal trabecular bone in the vicinity of the implants occurred as early as the first postoperative week in both groups. However, in general, the revascularization of the bone around the uncemented prostheses occurred more rapidly, resulting in earlier bone remodeling when compared with the cemented group. Surprisingly, the apposition of periosteal bone was longer lasting and more intensive in the uncemented group, particularly at the metaphyseal level. We suggest that this phenomenon may be enhanced by mechanical stimuli; the restoration of function was delayed in the noncemented goats.
我们研究了两组各6只成年雌性非洲侏儒山羊，它们的右髋分别接受了骨水泥型或非骨水泥型股骨假体。另外一只山羊用于术前和术后的体内血管造影。手术并未在宏观层面切断股骨近端的血液供应。术后第6周前，每周对动物实施安乐死。微血管造影和荧光显微镜检查显示，两组在术后第一周，植入物附近的干骺端小梁骨就开始快速血管再生。然而，总体而言，非骨水泥型假体周围的骨血管再生更快，与骨水泥型组相比，骨重塑更早出现。令人惊讶的是，非骨水泥型组骨膜骨的附着持续时间更长且更强烈，尤其是在干骺端水平。我们认为这种现象可能因机械刺激而增强；非骨水泥型山羊的功能恢复延迟。
