Division of Ophthalmology and Visual Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
Department of Ophthalmology, Yaoeda Eye Clinic, Nagaoka, Niigata, Japan.
PLoS One. 2020 Mar 5;15(3):e0229867. doi: 10.1371/journal.pone.0229867. eCollection 2020.
To estimate the central 10-degree visual field of glaucoma patients using en-face images obtained by optical coherence tomography (OCT), and to examine its usefulness.
Thirty-eight eyes of 38 patients with primary open angle glaucoma were examined. En-face images were obtained by swept-source OCT (SS-OCT). Nerve fiber bundles (NFBs) on en-face images at points corresponding to Humphrey Field Analyzer (HFA) 10-2 locations were identified with retinal ganglion cell displacement. Estimated visual fields were created based on the presence/absence of NFBs and compared to actual HFA10-2 data. κ coefficients were calculated between probability plots of visual fields and NFBs in en-face images.
Actual HFA10-2 data and estimated visual fields based on en-face images were well matched: when the test points of <5%, <2%, and <1% of the probability plot in total deviation (TD) and pattern deviation (PD) of HFA were defined as points with visual field defects, the κ coefficients were 0.58, 0.64, and 0.66 in TD, respectively, and 0.68, 0.69, and 0.67 in PD. In eyes with spherical equivalent ≥ -6 diopters, κ coefficients for <5%, <2%, and <1% were 0.58, 0.62, and 0.63 in TD and 0.66, 0.67, and 0.65 in PD, whereas for the myopic group with spherical equivalent < -6 diopters, the values were 0.58, 0.69, and 0.71 in TD and 0.72, 0.71, and 0.71 in PD, respectively. There was no statistically significant difference in κ coefficients between highly myopic eyes and eyes that were not highly myopic.
NFB defects in en-face images were correlated with HFA10-2 data. Using en-face images obtained by OCT, the central 10-degree visual field was estimated, and a high degree of concordance with actual HFA10-2 data was obtained. This method may be useful for detecting functional abnormalities based on structural abnormalities.
利用光学相干断层扫描（OCT）获得的共焦图像估计开角型青光眼患者的中央 10 度视野，并探讨其可用性。
对 38 例（38 只眼）原发性开角型青光眼患者进行检查。使用扫频源 OCT（SS-OCT）获取共焦图像。通过视网膜神经节细胞位移识别共焦图像上与 Humphrey 视野分析仪（HFA）10-2 位置相对应点的神经纤维束（NFB）。根据 NFB 的存在/缺失情况，基于该方法创建估计视野，并与实际 HFA10-2 数据进行比较。计算概率图中的视野和共焦图像中 NFB 之间的κ系数。
实际 HFA10-2 数据与基于共焦图像的估计视野非常吻合：当 HFA 总偏差（TD）和模式偏差（PD）中概率图<5%、<2%和<1%的测试点定义为视野缺损点时，TD 的 κ 系数分别为 0.58、0.64 和 0.66，PD 分别为 0.68、0.69 和 0.67。在等效球镜值≥-6 屈光度的眼中，<5%、<2%和<1%的 κ 系数在 TD 中分别为 0.58、0.62 和 0.63，在 PD 中分别为 0.66、0.67 和 0.65，而等效球镜值<-6 屈光度的近视组中，TD 分别为 0.58、0.69 和 0.71，PD 分别为 0.72、0.71 和 0.71。高度近视眼与非高度近视眼的 κ 系数无统计学差异。
共焦图像中的 NFB 缺陷与 HFA10-2 数据相关。利用 OCT 获得的共焦图像可以估计中央 10 度视野，并且与实际 HFA10-2 数据高度吻合。该方法可能有助于基于结构异常检测功能异常。
