Kurki R, Linder E, Miettinen A, Alfthan O, Heikkinen A, Pasternack A
Int J Cancer. 1977 Mar 15;19(3):332-6. doi: 10.1002/ijc.2910190308.
The presence of anti-tissue antibodies in sera from patients with genitourinary carcinomas and non-malignant genitourinary diseases was studied by indirect immunofluorescence. An increased incidence of various tissue antibodies was observed in carcinomas of the urinary bladder, prostate and kidney when compared to controls. There was a trend towards association between antinuclear antibodies and metastatic undifferentiated tumors. A low degree of malignancy was associated with antibodies against connective tissue "reticulin". A striking similarity between tissue antibody "patterns" in carcinoma patients and patients with chronic renal inflammation was seen. This points to inflammation as being an important factor in tissue antibody production.
通过间接免疫荧光法研究了泌尿生殖系统癌患者和非恶性泌尿生殖系统疾病患者血清中抗组织抗体的存在情况。与对照组相比，在膀胱癌、前列腺癌和肾癌中观察到各种组织抗体的发生率增加。抗核抗体与转移性未分化肿瘤之间存在关联趋势。低恶性程度与抗结缔组织“网状纤维”抗体有关。在癌症患者和慢性肾炎患者的组织抗体“模式”之间发现了惊人的相似性。这表明炎症是组织抗体产生的一个重要因素。
