百日咳博德特氏菌不会诱导β-肾上腺素能阻滞。
Bordetella pertussis does not induce beta-adrenergic blockade.
作者信息
Hewlett E, Spiegel A, Wolff J, Aurbach G, Manclark C R
出版信息
Infect Immun. 1978 Nov;22(2):430-4. doi: 10.1128/iai.22.2.430-434.1978.
Abstract
Bordetella pertussis organisms induce histamine sensitivity and diminish the normal hyperglycemic response to epinephrine in experimental animals. These effects have been attributed to beta-adrenergic blockade. However, under conditions in which the decrease in epinephrine-induced hyperglycemia after B. pertussis administration was demonstrable, there was no change in rat reticulocyte beta-adrenergic receptor number or affinity measured by iodohydroxybenzylpindolol binding or in isoproterenol-stimulated adenylate cyclase activity. Therefore, there was no generalized beta-adrenergic blockade induced by B. pertussis. The observed effects can be explained by the hypersecretion of insulin resulting from B. pertussis administration.
摘要
百日咳博德特氏菌可使实验动物对组胺敏感，并减弱其对肾上腺素正常的高血糖反应。这些作用被归因于β-肾上腺素能阻断。然而，在给予百日咳博德特氏菌后肾上腺素诱导的高血糖降低可被证实的情况下，通过碘羟基苄基吲哚洛尔结合法测定的大鼠网织红细胞β-肾上腺素能受体数量或亲和力，或异丙肾上腺素刺激的腺苷酸环化酶活性均无变化。因此，百日咳博德特氏菌并未诱导全身性β-肾上腺素能阻断。所观察到的效应可通过给予百日咳博德特氏菌后胰岛素的过度分泌来解释。
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本文引用的文献
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THE ABSENCE OF ADRENALINE-INDUCED HYPERGLYCEMIA IN PERTUSSIS- SENSITIZED MICE AND ITS RELATION TO HISTAMINE AND SEROTONIN HYPERSENSITIVITY.百日咳致敏小鼠中肾上腺素诱导的高血糖症缺失及其与组胺和5-羟色胺超敏反应的关系
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ADRENALINE MEDIATION OF HISTAMINE AND SEROTONIN HYPERGLYCEMIA IN NORMAL MICE AND THE ABSENCE OF ADRENALINE-INDUCED HYPERGLYCEMIA IN PERTUSSIS-SENSITIZED MICE.正常小鼠中组胺和血清素高血糖症的肾上腺素介导作用以及百日咳致敏小鼠中无肾上腺素诱导的高血糖症
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The altered reactivity of mice after inoculation with Bordetella pertussis vaccine.接种百日咳博德特氏菌疫苗后小鼠反应性的改变。
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The effect of epinephrine on immunoreactive insulin levels in man.肾上腺素对人体免疫反应性胰岛素水平的影响。
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