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多发性骨髓瘤的免疫治疗。

Immunotherapy in Multiple Myeloma.

机构信息

Department of Hematology-Oncology, National University Cancer Institute, Singapore, National University Health System, 1E Kent Ridge Road, Singapore 119228, Singapore.

出版信息

Cells. 2020 Mar 3;9(3):601. doi: 10.3390/cells9030601.

DOI:10.3390/cells9030601
PMID:32138182
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7140529/
Abstract

Multiple myeloma is a complex disease and immune dysfunction has been known to play an important role in the disease pathogenesis, progression, and drug resistance. Recent efforts in drug development have been focused on immunotherapies to modify the MM disease process. Here, we summarize the emerging immunotherapies in the MM treatment landscape.

摘要

多发性骨髓瘤是一种复杂的疾病,免疫功能障碍已被证实在疾病发病机制、进展和耐药性中发挥重要作用。最近药物研发的重点是免疫疗法,以改变 MM 的疾病进程。在这里,我们总结了多发性骨髓瘤治疗领域新兴的免疫疗法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a53a/7140529/14e7a182c7c2/cells-09-00601-g001a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a53a/7140529/14e7a182c7c2/cells-09-00601-g001a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a53a/7140529/14e7a182c7c2/cells-09-00601-g001a.jpg

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本文引用的文献

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Nat Cancer. 2020 Jan;1(1):86-98. doi: 10.1038/s43018-019-0004-z. Epub 2019 Nov 18.
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Defining an Optimal Dual-Targeted CAR T-cell Therapy Approach Simultaneously Targeting BCMA and GPRC5D to Prevent BCMA Escape-Driven Relapse in Multiple Myeloma.定义一种最优的双靶点 CAR T 细胞治疗方法,同时靶向 BCMA 和 GPRC5D,以预防多发性骨髓瘤中因 BCMA 逃逸驱动的复发。
Blood Cancer Discov. 2020 Sep;1(2):146-154. doi: 10.1158/2643-3230.BCD-20-0020.
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靶向免疫疗法:利用免疫系统对抗多发性骨髓瘤。
Cell Death Discov. 2024 Jan 27;10(1):55. doi: 10.1038/s41420-024-01818-6.
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Multiplex immunohistochemistry elucidates increased distance between cytotoxic T cells and plasma cells in relapsed myeloma, and identifies Lag-3 as the most common checkpoint receptor on cytotoxic T cells of myeloma patients.多重免疫组化阐明了复发性骨髓瘤中细胞毒性 T 细胞和浆细胞之间距离的增加,并确定了 Lag-3 为骨髓瘤患者细胞毒性 T 细胞上最常见的检查点受体。
Haematologica. 2024 May 1;109(5):1487-1500. doi: 10.3324/haematol.2023.283344.
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Cancers (Basel). 2023 May 27;15(11):2948. doi: 10.3390/cancers15112948.
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