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乳腺密度通知:澳大利亚视角

Breast Density Notification: An Australian Perspective.

作者信息

Ingman Wendy V, Richards Bernadette, Street Jacqueline M, Carter Drew, Rickard Mary, Stone Jennifer, Dasari Pallave

机构信息

Adelaide Medical School based at The Queen Elizabeth Hospital, University of Adelaide, Adelaide, SA 5011, Australia.

Robinson Research Institute, University of Adelaide, Adelaide, SA 5005, Australia.

出版信息

J Clin Med. 2020 Mar 3;9(3):681. doi: 10.3390/jcm9030681.

DOI:10.3390/jcm9030681
PMID:32138307
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7141298/
Abstract

Breast density, also known as mammographic density, refers to white and bright regions on a mammogram. Breast density can only be assessed by mammogram and is not related to how breasts look or feel. Therefore, women will only know their breast density if they are notified by the radiologist when they have a mammogram. Breast density affects a woman's breast cancer risk and the sensitivity of a screening mammogram to detect cancer. Currently, the position of BreastScreen Australia and the Royal Australian and New Zealand College of Radiologists is to not notify women if they have dense breasts. However, patient advocacy organisations are lobbying for policy change. Whether or not to notify women of their breast density is a complex issue and can be framed within the context of both public health ethics and clinical ethics. Central ethical themes associated with breast density notification are equitable care, patient autonomy in decision-making, trust in health professionals, duty of care by the physician, and uncertainties around evidence relating to measurement and clinical management pathways for women with dense breasts. Legal guidance on this issue must be gained from broad legal principles found in the law of negligence and the test of materiality. We conclude a rigid legal framework for breast density notification in Australia would not be appropriate. Instead, a policy framework should be developed through engagement with all stakeholders to understand and take account of multiple perspectives and the values at stake.

摘要

乳腺密度,也称为乳房X线摄影密度,指的是乳房X线照片上的白色明亮区域。乳腺密度只能通过乳房X线照片来评估,与乳房的外观或触感无关。因此,只有在进行乳房X线检查时放射科医生告知,女性才会知道自己的乳腺密度。乳腺密度会影响女性患乳腺癌的风险以及筛查性乳房X线检查检测癌症的敏感性。目前,澳大利亚乳房筛查机构以及澳大利亚和新西兰皇家放射科医师学院的立场是,如果女性乳房密度高,不会告知她们。然而,患者权益倡导组织正在游说政策变革。是否告知女性其乳腺密度是一个复杂的问题,可以在公共卫生伦理和临床伦理的背景下进行探讨。与乳腺密度告知相关的核心伦理主题包括公平护理、患者决策自主权、对医疗专业人员的信任、医生的护理职责以及与乳腺密度高的女性的测量和临床管理途径相关证据的不确定性。关于这个问题的法律指导必须从过失法中的广泛法律原则和重要性测试中获得。我们得出结论,在澳大利亚建立一个严格的乳腺密度告知法律框架是不合适的。相反,应该通过与所有利益相关者合作来制定一个政策框架,以理解并考虑到多种观点和利害关系中的价值观。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cf6/7141298/348ccd254113/jcm-09-00681-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cf6/7141298/348ccd254113/jcm-09-00681-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cf6/7141298/348ccd254113/jcm-09-00681-g001.jpg

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本文引用的文献

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Supplemental MRI Screening for Women with Extremely Dense Breast Tissue.致密型乳腺女性的补充性磁共振成像筛查。
N Engl J Med. 2019 Nov 28;381(22):2091-2102. doi: 10.1056/NEJMoa1903986.
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Two-view digital breast tomosynthesis versus digital mammography in a population-based breast cancer screening programme (To-Be): a randomised, controlled trial.基于人群的乳腺癌筛查项目中两视图数字乳腺断层合成与数字乳腺钼靶摄影的比较(To-Be):一项随机对照试验。
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One-view breast tomosynthesis versus two-view mammography in the Malmö Breast Tomosynthesis Screening Trial (MBTST): a prospective, population-based, diagnostic accuracy study.
南澳大利亚接受乳腺癌筛查女性中与乳腺密度知识增加相关的因素
Cancers (Basel). 2024 Feb 23;16(5):893. doi: 10.3390/cancers16050893.
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A scoping review of programme specific mammographic breast density related guidelines and practices within breast screening programmes.一项针对乳腺筛查项目中与乳房X线摄影乳腺密度相关的特定项目指南和实践的范围综述。
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Australian Women's Responses to Breast Density Information: A Content Analysis.澳大利亚女性对乳腺密度信息的反应:内容分析。
Int J Environ Res Public Health. 2023 Jan 16;20(2):1596. doi: 10.3390/ijerph20021596.
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Breast ultrasound in breast cancer surveillance; incremental cancers found at what cost?乳腺癌监测中的乳腺超声:以什么为代价发现的新增癌症?
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单视图乳腺断层合成摄影术与两视图乳腺 X 线摄影术在马尔默乳腺断层合成摄影术筛查试验(MBTST)中的比较:一项前瞻性、基于人群的、诊断准确性研究。
Lancet Oncol. 2018 Nov;19(11):1493-1503. doi: 10.1016/S1470-2045(18)30521-7. Epub 2018 Oct 12.
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Addition of ultrasound to mammography in the case of dense breast tissue: systematic review and meta-analysis.在乳腺组织致密的情况下,将超声与乳房 X 光摄影相结合:系统评价和荟萃分析。
Br J Cancer. 2018 Jun;118(12):1559-1570. doi: 10.1038/s41416-018-0080-3. Epub 2018 May 8.
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Aggressive primary treatments with favourable 5-year survival for screen-interval breast cancers.对处于筛查间期的乳腺癌进行积极的初级治疗,可获得良好的 5 年生存率。
BMC Cancer. 2018 Apr 6;18(1):393. doi: 10.1186/s12885-018-4319-4.
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Population-Attributable Risk Proportion of Clinical Risk Factors for Breast Cancer.临床乳腺癌风险因素的人群归因危险度比例。
JAMA Oncol. 2017 Sep 1;3(9):1228-1236. doi: 10.1001/jamaoncol.2016.6326.
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Digital mammography screening: sensitivity of the programme dependent on breast density.数字化乳腺钼靶筛查:该项目的敏感性取决于乳腺密度。
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Supplemental Screening for Breast Cancer in Women With Dense Breasts: A Systematic Review for the U.S. Preventive Services Task Force.乳腺致密女性的乳腺癌补充筛查:美国预防服务工作组的系统评价
Ann Intern Med. 2016 Feb 16;164(4):268-78. doi: 10.7326/M15-1789. Epub 2016 Jan 12.
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Sensitivity and specificity of mammography and adjunctive ultrasonography to screen for breast cancer in the Japan Strategic Anti-cancer Randomized Trial (J-START): a randomised controlled trial.钼靶 X 线摄影和附加超声检查筛查乳腺癌的敏感性和特异性:日本策略性抗癌随机试验(J-START):一项随机对照试验。
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Am J Epidemiol. 2015 Nov 15;182(10):863-7. doi: 10.1093/aje/kwv193. Epub 2015 Oct 31.