Chemical and Environmental Engineering Department, University of the Basque Country (UPV/EHU), Plaza Europa, 1, 20018 Donostia-San Sebastián, Spain.
Department of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute-Donostia University Hospital, University of the Basque Country (UPV/EHU), 20014 Donostia-San Sebastián, Spain.
Molecules. 2020 Mar 3;25(5):1131. doi: 10.3390/molecules25051131.
The growing concern about the environmental impact and human health risk related to the excessive use of synthetic ingredients in cosmetics and topical formulations calls for the exploration of safe and sustainable natural alternatives. Lignin-rich lignocellulosic industrial wastes such as hazelnut and walnut shells were used as a lignin polymer source. Agro-derived lignins were evaluated as a potential natural active ingredient for health care products. Aside from the structural characteristics of isolated lignins, which were identified by GPC, Py-GC-MS, and 2D HSQC NMR techniques, functional properties such as antioxidant power and UV absorption ability were investigated. The SPF values found for creams containing 5% of hazelnut and walnut lignin content were 6.9 and 4.5, respectively. Additionally, both lignin types presented appropriate protection against UVA radiation, highly interesting property to block the full ultraviolet spectrum. The biological activity of isolated lignins assessed at different concentrations (0.01-1 mg/mL) and different times (24, 48, and 72 h) on murine fibroblast cell line 3T3 suggested their suitability for cosmetic applications.
人们越来越关注化妆品和局部制剂中过度使用合成成分对环境和人类健康的风险，因此需要探索安全和可持续的天然替代品。榛子和核桃壳等富含木质素的木质纤维素工业废料被用作木质素聚合物的来源。农业衍生木质素被评估为一种有潜力的天然活性成分，可用于保健产品。除了通过 GPC、Py-GC-MS 和 2D HSQC NMR 技术鉴定的分离木质素的结构特征外，还研究了其抗氧化能力和紫外线吸收能力等功能特性。含有 5%榛子和核桃木质素的乳膏的 SPF 值分别为 6.9 和 4.5。此外，这两种木质素类型都对 UVA 辐射表现出适当的保护作用，这是阻止全紫外线光谱的高度有趣的特性。在不同浓度（0.01-1mg/ml）和不同时间（24、48 和 72 小时）下，对 3T3 鼠成纤维细胞系进行的分离木质素的生物学活性评估表明，它们适合用于化妆品应用。
