Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.
Cancer Research Institute, Seoul National University, Seoul, Korea.
Cancer Res Treat. 2020 Jul;52(3):848-854. doi: 10.4143/crt.2019.550. Epub 2020 Mar 6.
We aimed to assess the association between the dietary intake of fish-derived omega-3 polyunsaturated fatty acids and the risk of colorectal cancer among Swedish women.
A total of 48,233 women with information on dietary intake were included in the analysis. Participants were followed for incident colorectal cancer until 31 December 2012. Cox proportional hazard models were used to assess the association between baseline fatty acid intake and colorectal cancer risk. All analyses were stratified by colon and rectal cancers.
During a median of 21.3 years of follow-up, a total of 344 colorectal cancer cases were ascertained. Although there was no overall association between omega-3 fatty acid intake and colorectal cancer risk, high intake of fish-derived docosahexaenoic acid was associated with reduced risk of rectal cancer (hazard ratios for the third and the highest quartiles were 0.59 (95% confidence interval [CI], 0.37 to 0.96) and 0.62 (95% CI, 0.39 to 0.98), respectively).
In conclusion, we found only limited support for an association between omega-3 polyunsaturated fatty acids and colorectal cancer in a large Swedish cohort of middle-aged women.
我们旨在评估鱼类衍生的 ω-3 多不饱和脂肪酸的饮食摄入量与瑞典女性结直肠癌风险之间的关联。
共有 48233 名女性的饮食摄入信息纳入分析。参与者在结直肠癌发病前接受了 31 日 2012 年 12 月的随访。使用 Cox 比例风险模型评估基线脂肪酸摄入量与结直肠癌风险之间的关联。所有分析均按结肠癌和直肠癌分层。
在中位数为 21.3 年的随访期间，共确定了 344 例结直肠癌病例。尽管 ω-3 脂肪酸摄入与结直肠癌风险之间没有总体关联，但高摄入鱼类衍生的二十二碳六烯酸与直肠癌风险降低相关（第三和最高四分位数的风险比分别为 0.59（95%置信区间，0.37 至 0.96）和 0.62（95%置信区间，0.39 至 0.98））。
综上所述，我们在一个大型的瑞典中年女性队列中仅发现了有限的支持ω-3 多不饱和脂肪酸与结直肠癌之间存在关联的证据。
