Department of Experimental and Clinical Medicine, University of Catanzaro "Magna Graecia", Catanzaro, Italy.
National Center for Drug Research and Evaluation, National Institute of Health, Rome, Italy.
J Exp Clin Cancer Res. 2020 Mar 5;39(1):48. doi: 10.1186/s13046-020-01549-3.
Molecular profiling of DNA and RNA has provided valuable new insights into the genetic basis of non-malignant and malignant disorders, as well as an increased understanding of basic mechanisms that regulate human disease. Recent technological advances have enabled the analyses of alterations in gene-based structure or function in a comprehensive, high-throughput fashion showing that each tumor type typically exhibits distinct constellations of genetic alterations targeting one or more key cellular pathways that regulate cell growth and proliferation, evasion of the immune system, and other aspects of cancer behavior. These advances have important implications for future research and clinical practice in areas as molecular diagnostics, the implementation of gene or pathway-directed targeted therapy, and the use of such information to drive drug discovery. The 1st international and 32nd Annual Conference of Italian Association of Cell Cultures (AICC) conference wanted to offer the opportunity to match technological solutions and clinical needs in the era of precision medicine.
DNA 和 RNA 的分子谱分析为非恶性和恶性疾病的遗传基础提供了有价值的新见解，并提高了对调节人类疾病的基本机制的理解。最近的技术进步使我们能够以全面、高通量的方式分析基于基因的结构或功能的改变，结果表明，每种肿瘤类型通常表现出独特的基因改变组合，针对一个或多个关键细胞通路，这些通路调节细胞生长和增殖、逃避免疫系统以及癌症行为的其他方面。这些进展对未来的研究和临床实践具有重要意义，如分子诊断、实施基因或通路导向的靶向治疗，以及利用这些信息来推动药物发现。第 1 届国际和第 32 届意大利细胞培养协会（AICC）年会旨在为精准医学时代的技术解决方案和临床需求提供匹配的机会。
