Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, United States.
Int Rev Cell Mol Biol. 2020;350:265-284. doi: 10.1016/bs.ircmb.2019.10.005. Epub 2019 Nov 8.
Virus exploits host cellular machinery to replicate and form new viral progeny and endoplasmic reticulum (ER) plays central role in the interplay between virus and host cell. Here I will discuss how cellular functions of ER being utilized by viruses from different families during different stages of pathogenesis. Flow of knowledge related to this area of research based on interdisciplinary approach, using biochemical and cell biological assays coupled with advanced microscopy strategies, is pushing our understanding of the virus-ER interaction during infection to the next level.
病毒利用宿主细胞机制进行复制并形成新的病毒后代，内质网（ER）在病毒与宿主细胞的相互作用中发挥核心作用。在这里，我将讨论不同病毒家族在发病的不同阶段如何利用 ER 的细胞功能。基于跨学科方法，利用生化和细胞生物学检测方法与先进的显微镜策略相结合，使与该研究领域相关的知识不断流动，将我们对感染过程中病毒-ER 相互作用的理解推向了一个新的水平。
