Institute of Agricultural Economics and Development, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.
John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, 02138, USA.
Anal Chim Acta. 2020 Apr 8;1105:208-213. doi: 10.1016/j.aca.2020.01.051. Epub 2020 Jan 24.
Exposure to even very low concentration of Pb can cause neurological and developmental disorders, and affects children more severely. Neuromelanin (NM) in the substantial nigra can trap endogenous and environmental toxins and immobilize them as stable adducts, thus protecting brain against toxicity. Until now, the structure and Pb-chelating ability of NM is still little understood. Here, we prepare a mimicking NM by amino acid and dopamine. The prepared NM has strong fluorescent and its fluorescence can be quenched by Pb. This study offers a novel way to synthetic NM and provides an effective method to detect Pb.
即使暴露在极低浓度的铅下也会导致神经和发育障碍，并且对儿童的影响更严重。黑质中的神经黑色素 (NM) 可以捕获内源性和环境毒素，并将其固定为稳定的加合物，从而保护大脑免受毒性影响。到目前为止，NM 的结构和铅螯合能力仍知之甚少。在这里，我们通过氨基酸和多巴胺制备了一种模拟 NM。所制备的 NM 具有很强的荧光，其荧光可以被 Pb 猝灭。这项研究提供了一种合成 NM 的新方法，并为检测 Pb 提供了一种有效方法。
