利用免疫代谢和 T 细胞功能进行实体器官移植。
Exploiting immunometabolism and T cell function for solid organ transplantation.
机构信息
Department of Medicine, Section of Rheumatology, The University of Chicago, Chicago, IL 60637, United States.
Department of Medicine, Section of Rheumatology, The University of Chicago, Chicago, IL 60637, United States.
出版信息
Cell Immunol. 2020 May;351:104068. doi: 10.1016/j.cellimm.2020.104068. Epub 2020 Feb 19.
Abstract
Cellular metabolism is central to T cell function and proliferation, with most of the research to date focusing on cancer and autoimmunity. Cellular metabolism is associated with a host of physiological phenomena, from epigenetic changes, to cellular function and fate. For the purpose of this review, we will discuss the metabolism of T cells relating to their differentiation and function. We will cover a variety of metabolic processes, ranging from glycolysis to amino acid metabolism. Understanding how T cell metabolism informs T cell function may be useful to understand alloimmune responses and design novel therapies to improve graft outcome.
摘要
细胞代谢是 T 细胞功能和增殖的核心，迄今为止，大多数研究都集中在癌症和自身免疫上。细胞代谢与许多生理现象有关，从表观遗传变化到细胞功能和命运。为了进行本次综述，我们将讨论与 T 细胞分化和功能相关的代谢。我们将涵盖各种代谢过程，从糖酵解到氨基酸代谢。了解 T 细胞代谢如何影响 T 细胞功能，可能有助于理解同种免疫反应，并设计新的治疗方法来改善移植物的预后。
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