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新生儿肿瘤的临床表现与外科治疗:回顾性分析

Clinical Presentation and Surgical Management of Neonatal Tumors: Retrospective Analysis.

作者信息

Solanki Shailesh, Menon Prema, Samujh Ram, Gupta Kirti, Rao K L N

机构信息

Department of Pediatric Surgery, PGIMER, Chandigarh, India.

Department of Pathology, PGIMER, Chandigarh, India.

出版信息

J Indian Assoc Pediatr Surg. 2020 Mar-Apr;25(2):85-90. doi: 10.4103/jiaps.JIAPS_241_18. Epub 2020 Jan 28.

Abstract

AIMS

Neonatal tumors (NTs) include a group of diverse neoplasms. In this study, we reviewed our data for clinical presentations, management options, and outcome.

MATERIALS AND METHODS

All patients from 0- to 1-month age presenting with solid tumors, from 2006 to 2018 were studied. The gender, presentation, location, type of tumor, and management were analyzed. The final diagnosis was made with histopathology in all cases. Hemangiomas and lymphangiomas were excluded from the study.

RESULTS

A total of 32 neonates were studied. The most common tumor was sacrococcygeal teratoma (SCT,16) followed by teratoma at other sites including two cases of fetus-in-fetu, soft-tissue sarcoma (STS, 4), mesenchymal hamartoma (2), hemangioendothelioma (2), and other rare tumors. Three tumors were diagnosed antenatally; of whom, two were neither visible externally nor palpable. Complete surgical excision was done for all except in a case of ovarian cyst where near-total cystectomy was done. No patient received chemotherapy or radiotherapy. Six patients had postoperative complications, including two who had local recurrence requiring excision. There was one mortality. All the other patients are doing well during follow-up.

CONCLUSION

NTs have varied presentations. SCT and STS were the most common benign and malignant tumor, respectively. Early diagnosis and complete surgical excision are often curative for all, regardless of the pathology with the minimal role of chemotherapy or radiotherapy.

摘要

目的

新生儿肿瘤(NTs)包括一组多样的肿瘤。在本研究中,我们回顾了有关临床表现、治疗选择和预后的数据。

材料与方法

研究了2006年至2018年所有0至1个月龄出现实体瘤的患者。分析了性别、表现、部位、肿瘤类型和治疗情况。所有病例均通过组织病理学做出最终诊断。血管瘤和淋巴管瘤被排除在研究之外。

结果

共研究了32例新生儿。最常见的肿瘤是骶尾部畸胎瘤(SCT,16例),其次是其他部位的畸胎瘤,包括2例胎中胎、软组织肉瘤(STS,4例)、间叶性错构瘤(2例)、血管内皮瘤(2例)和其他罕见肿瘤。3例肿瘤在产前被诊断;其中2例在外部既不可见也不可触及。除1例卵巢囊肿行近全囊肿切除术外,所有患者均行完整手术切除。没有患者接受化疗或放疗。6例患者有术后并发症,其中2例局部复发需要切除。有1例死亡。所有其他患者在随访期间情况良好。

结论

NTs有多种表现形式。SCT和STS分别是最常见的良性和恶性肿瘤。早期诊断和完整手术切除通常对所有患者都有治愈作用,无论病理情况如何,化疗或放疗的作用最小。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7a0/7020687/a46d7f23fb09/JIAPS-25-85-g001.jpg

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