Forbes Jessica, Heydari Milad, Kesselman Marc M, Villacorta Miguel
Dermatology, Dr. Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University, Davie, USA.
Rheumatology, Dr. Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University, Davie, USA.
Cureus. 2020 Jan 27;12(1):e6788. doi: 10.7759/cureus.6788.
Cutaneous polyarteritis nodosum (CPAN) is a vasculitis of small and medium-sized muscular arteries of the dermis and subcutaneous tissue with no associated systemic involvement. A common presentation of CPAN can be misinterpreted as a non-invasive form of livedoid vasculitis, synonymous with the "atrophie blanche" which similarly presents as ivory-white stellate-shaped scars. Although hyperpigmentation can also be present, as seen in our 47-year-old female patient, cutaneous polyarteritis nodosum is unique due to the etiology of the inflammatory illness which requires a deep, segmented skin biopsy for diagnosis in order to identify the vessel inflammation. In this case report, we discuss a patient with a 20-year history of painful, recurrent ulcerations and polyneuritis with previous ulcer eruptions that healed as ivory-white stellate scarring. AB cutaneous forms of polyarteritis nodosum (PAN) may be only one manifestation of the disease, with other presentations in association with multi-organ system disease. This report will discuss the necessity of a high index of clinical suspicion with a clinical presentation similar to that of our patient. We will discuss the importance of early recognition and diagnosis of cutaneous vasculitis, such as CPAN, based on clinical presentation and history in hopes of limiting morbidity and the risk of progression to systemic forms of the disease.
皮肤结节性多动脉炎(CPAN)是一种真皮和皮下组织中小、中型肌性动脉的血管炎,无相关系统性受累。CPAN的常见表现可能被误解为一种非侵袭性的类脂质渐进性坏死性血管炎,与同样表现为象牙白色星状瘢痕的“白色萎缩”同义。虽然也可能出现色素沉着,如我们47岁的女性患者所见,但皮肤结节性多动脉炎因其炎症性疾病的病因独特,需要进行深部、分段皮肤活检以诊断,从而识别血管炎症。在本病例报告中,我们讨论了一名有20年疼痛、复发性溃疡和多神经炎病史的患者,既往溃疡发作后愈合为象牙白色星状瘢痕。皮肤型结节性多动脉炎(PAN)可能只是该疾病的一种表现,还有其他表现与多器官系统疾病相关。本报告将讨论对于与我们患者临床表现相似的情况保持高度临床怀疑的必要性。我们将基于临床表现和病史讨论早期识别和诊断皮肤血管炎如CPAN的重要性,以期限制发病率以及进展为系统性疾病形式的风险。