Suppr超能文献

成年患者慢性创伤性脑病与血管炎之间的关联及结局

Associations and Outcomes Between Chronic Traumatic Encephalopathy and Vasculitis in Adult Patients.

作者信息

Adjepong Dennis, Malik Bilal Haider

机构信息

Neurological Surgery, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA.

Internal Medicine, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA.

出版信息

Cureus. 2020 Jan 28;12(1):e6795. doi: 10.7759/cureus.6795.

Abstract

Chronic traumatic encephalopathy (CTE) results from brain injuries and traumas due to accelerated impacts on the head. In severe cases, the diseases cause brain damage, given the head trauma. On the other hand, vasculitis occurs through antibodies that mistake protein vessels as foreign, hence fighting them and resulting in their damage. Examination is usually conducted through blood tests, with antibodies being identified in the antineutrophil cytoplasm. It is unfortunate that its devastating effects also affect the brain of a human, hence leading to dis-functioning. When vasculitis is left untreated, it results in multiple adverse effects on the human body and health both in the short term and in the long term. This study aims to bring to the awareness of neurosurgeons the associations between CTE and vasculitis. This study has proved that there is a close correlation between the progression of CTE and vasculitis. The inflammatory of the blood vessels, as witnessed in vasculitis, increases the risk factors for CTE. The scaling of the vessels and manifestation of different vasculitis conditions in active central nervous system cells results in the worsening of neurodegeneration of the CTE disease.

摘要

慢性创伤性脑病(CTE)是由头部加速撞击导致的脑损伤和创伤引起的。在严重情况下,鉴于头部创伤,这些疾病会导致脑损伤。另一方面,血管炎是通过抗体将蛋白质血管误认为外来物而发生的,因此会攻击它们并导致其损伤。通常通过血液检测进行检查,在抗中性粒细胞胞浆中可识别出抗体。不幸的是,其破坏性影响也会影响人类大脑,从而导致功能失调。当血管炎得不到治疗时,无论在短期还是长期都会对人体和健康产生多种不良影响。本研究旨在让神经外科医生了解CTE与血管炎之间的关联。这项研究已证明CTE的进展与血管炎之间存在密切相关性。如在血管炎中所见,血管的炎症增加了CTE的风险因素。血管的扩张以及活跃的中枢神经系统细胞中不同血管炎状况的表现会导致CTE疾病神经退行性变的恶化。

相似文献

5
Post-traumatic neurodegeneration and chronic traumatic encephalopathy.创伤后神经退行性变与慢性创伤性脑病
Mol Cell Neurosci. 2015 May;66(Pt B):81-90. doi: 10.1016/j.mcn.2015.03.007. Epub 2015 Mar 7.
6
Repetitive Head Impacts and Chronic Traumatic Encephalopathy.重复性头部撞击与慢性创伤性脑病
Neurosurg Clin N Am. 2016 Oct;27(4):529-35. doi: 10.1016/j.nec.2016.05.009.
7
The neuropathology of chronic traumatic encephalopathy.慢性创伤性脑病的神经病理学
Handb Clin Neurol. 2018;158:297-307. doi: 10.1016/B978-0-444-63954-7.00028-8.

引用本文的文献

本文引用的文献

1
Leveraging Genetic Findings for Precision Medicine in Vasculitis.利用遗传学研究成果推进血管炎精准医疗
Front Immunol. 2019 Aug 2;10:1796. doi: 10.3389/fimmu.2019.01796. eCollection 2019.
2
Chronic Traumatic Encephalopathy: A Brief Overview.慢性创伤性脑病:简要概述
Front Neurol. 2019 Jul 3;10:713. doi: 10.3389/fneur.2019.00713. eCollection 2019.
3
Vasculitis and peripheral neuropathy.血管炎和周围神经病。
Curr Opin Rheumatol. 2019 Jan;31(1):40-45. doi: 10.1097/BOR.0000000000000559.
4
Variation in TMEM106B in chronic traumatic encephalopathy.TMEM106B 变异与慢性创伤性脑病。
Acta Neuropathol Commun. 2018 Nov 4;6(1):115. doi: 10.1186/s40478-018-0619-9.
5
Diagnosis and differential diagnosis of large-vessel vasculitides.大血管血管炎的诊断和鉴别诊断。
Rheumatol Int. 2019 Feb;39(2):169-185. doi: 10.1007/s00296-018-4157-3. Epub 2018 Sep 17.
8
The nonsystemic vasculitic neuropathies.非系统性血管炎性神经病。
Nat Rev Neurol. 2017 Apr 27;13(5):302-316. doi: 10.1038/nrneurol.2017.42.
9
Chronic Traumatic Encephalopathy: Known Causes, Unknown Effects.慢性创伤性脑病:已知病因,未知影响。
Phys Med Rehabil Clin N Am. 2017 May;28(2):301-321. doi: 10.1016/j.pmr.2016.12.007. Epub 2017 Mar 8.
10
Central nervous system vasculitis in adults: An update.成人中枢神经系统血管炎:更新。
Autoimmun Rev. 2017 Feb;16(2):123-131. doi: 10.1016/j.autrev.2016.12.001. Epub 2017 Jan 11.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验