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哮喘患者与非哮喘患者的免疫球蛋白E抗体水平比较。

immunoglobulin E antibody levels in patients with asthma compared with non-asthma.

作者信息

Smith-Norowitz Tamar A, Loeffler Jeffrey, Huang Yvonne, Klein Elliot, Norowitz Yitzchok M, Hammerschlag Margaret R, Joks Rauno, Kohlhoff Stephan

机构信息

Department of Pediatrics, Division of Infectious Diseases, State University of New York Downstate Medical Center, Brooklyn, New York, 11203, USA.

Department of Medicine, State University of New York Downstate Medical Center, Brooklyn, New York, 11203, USA.

出版信息

Heliyon. 2020 Feb 29;6(2):e03512. doi: 10.1016/j.heliyon.2020.e03512. eCollection 2020 Feb.

Abstract

is an obligate intracellular bacterium that causes respiratory infection in adults and children. There is evidence for an association between atypical bacterial pathogens and asthma pathogenesis. We sought to determine whether past infection triggers - IgE antibodies (Abs) in asthmatics and non-asthmatics, who had detectable IgG titers. IgE Abs were quantified using enzyme immunoassay (EIA). IgE Ab levels were higher in asthmatics compared with non-asthmatics. There was no correlation found between total serum IgE levels and specific IgE Ab levels. infection may trigger IgE-specific responses in asthmatics.

摘要

是一种专性细胞内细菌,可引起成人和儿童的呼吸道感染。有证据表明非典型细菌病原体与哮喘发病机制之间存在关联。我们试图确定既往感染是否会触发哮喘患者和非哮喘患者体内的IgE抗体(Abs),这些患者的IgG滴度可检测到。使用酶免疫测定(EIA)对IgE Abs进行定量。与非哮喘患者相比,哮喘患者的IgE Ab水平更高。未发现总血清IgE水平与特异性IgE Ab水平之间存在相关性。感染可能会触发哮喘患者的IgE特异性反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c01/7052057/c4a15afb7f2c/gr1.jpg

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