Sun Hong, Wang Weiqun, Lin Chenglei, Chen Min
Department of Pediatrics, Zhejiang Hospital of Integrated Traditional Chinese and Western Medicine, Hangzhou, Zhejiang 310003, China.
Department of Pediatrics, Qingyang People's Hospital of Gansu Province, Qingyang, Gansu 745000, China.
Evid Based Complement Alternat Med. 2021 Oct 28;2021:7368642. doi: 10.1155/2021/7368642. eCollection 2021.
To investigate the correlation between serum immune factor levels and allergic constitution in children with infectious mononucleosis.
A total of 120 children who visited our hospital from March, 2019, to December, 2020, were selected as the research objects, and 40 children who came to our hospital for physical examination were included in the control group (CG). 40 children with IM were classified into the IM group (IG), and 40 IM children with allergic rhinitis, allergic dermatitis, asthma, and other allergic diseases were classified into the IM allergy group (AG). On the second day of admission, 5 ml of fasting venous blood was collected from all children in the early morning to observe the serum IgE level, the level of lymphocyte subsets, and the level of immunoglobulin of the patient.
The serum CD3, CD4, and CD8 levels of children in AG were significantly higher than those in IG and CG ( < 0.05). The serum IgE, IgA, IgM, and IgG levels of children in AG were significantly higher than those of IG and CG ( < 0.05). The serum IgE levels of children in AG were positively correlated with the serum CD3, CD4, and CD8 levels ( < 0.05). There was a positive correlation between the serum IgE level and serum IgA, IgM, and IgG levels in children with AG ( < 0.05).
The results of this study showed that there may be a certain relationship between allergic constitution and the incidence, clinical manifestations, and prognosis of infectious mononucleosis. IgE level can be used as a reference index for the early severity of IM clinical symptoms.
探讨传染性单核细胞增多症患儿血清免疫因子水平与过敏体质之间的相关性。
选取2019年3月至2020年12月来我院就诊的120例患儿作为研究对象，将40例来我院进行体检的儿童纳入对照组（CG）。40例传染性单核细胞增多症（IM）患儿分为IM组（IG），40例患有过敏性鼻炎、过敏性皮炎、哮喘等过敏性疾病的IM患儿分为IM过敏组（AG）。入院次日清晨采集所有患儿5ml空腹静脉血，观察患者血清IgE水平、淋巴细胞亚群水平及免疫球蛋白水平。
AG组患儿血清CD3、CD4和CD8水平显著高于IG组和CG组（P<0.05）。AG组患儿血清IgE、IgA、IgM和IgG水平显著高于IG组和CG组（P<0.05）。AG组患儿血清IgE水平与血清CD3、CD4和CD8水平呈正相关（P<0.05）。AG组患儿血清IgE水平与血清IgA、IgM和IgG水平呈正相关（P<0.05）。
本研究结果表明，过敏体质与传染性单核细胞增多症的发病、临床表现及预后可能存在一定关系。IgE水平可作为IM临床症状早期严重程度的参考指标。
