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肝细胞癌——如何确定治疗方案

Hepatocellular Carcinoma-How to Determine Therapeutic Options.

作者信息

Mehta Neil

机构信息

Division of Gastroenterology Department of Medicine University of California San Francisco San Francisco CA.

出版信息

Hepatol Commun. 2020 Jan 22;4(3):342-354. doi: 10.1002/hep4.1481. eCollection 2020 Mar.

DOI:10.1002/hep4.1481
PMID:32140653
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7049673/
Abstract

Deciding on specific treatment strategies involves not only tumor stage, performance status, and severity of underlying liver disease, but additional factors such as biomarkers, organ availability, and radiographic tumor response to treatment. In this review, we present hepatocellular carcinoma (HCC) cases to highlight how to determine therapeutic options for HCC in specific scenarios, including resection versus liver transplant, choice of initial local regional treatment, tumor downstaging, and systemic therapies for advanced HCC.

摘要

确定具体的治疗策略不仅涉及肿瘤分期、身体状况和潜在肝脏疾病的严重程度，还涉及其他因素，如生物标志物、器官可用性以及肿瘤对治疗的影像学反应。在本综述中，我们展示肝细胞癌（HCC）病例，以突出在特定情况下如何确定HCC的治疗方案，包括手术切除与肝移植、初始局部区域治疗的选择、肿瘤降期以及晚期HCC的全身治疗。

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Hepatocellular Carcinoma-How to Determine Therapeutic Options.肝细胞癌——如何确定治疗方案
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本文引用的文献

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The impact of portal vein tumor thrombus on long-term survival after liver resection for primary hepatic malignancy.门静脉癌栓对原发性肝癌肝切除术后长期生存的影响。
HPB (Oxford). 2020 Jul;22(7):1025-1033. doi: 10.1016/j.hpb.2019.10.2439. Epub 2019 Nov 13.
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Improved clinical outcome using transarterial chemoembolization combined with radiofrequency ablation for patients in Barcelona clinic liver cancer stage A or B hepatocellular carcinoma regardless of tumor size: results of a single-center retrospective case control study.经导管动脉化疗栓塞联合射频消融治疗巴塞罗那临床肝癌分期 A 或 B 期肝细胞癌患者的临床结局改善，无论肿瘤大小：单中心回顾性病例对照研究结果。
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Locoregional treatments for hepatocellular carcinoma: Current evidence and future directions.局部区域治疗肝细胞癌：当前证据和未来方向。
World J Gastroenterol. 2019 Aug 28;25(32):4614-4628. doi: 10.3748/wjg.v25.i32.4614.
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Chemoembolization Combined with Radiofrequency Ablation for Medium-Sized Hepatocellular Carcinoma: A Propensity-Score Analysis.经导管化疗栓塞联合射频消融治疗中等大小肝细胞癌的疗效分析：倾向评分匹配研究。
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J Hepatol. 2019 Sep;71(3):473-485. doi: 10.1016/j.jhep.2019.04.017. Epub 2019 May 13.