Symbiosis School of Biological Sciences, Symbiosis International (Deemed University), Pune, India.
Crit Rev Microbiol. 2020 Mar;46(2):136-146. doi: 10.1080/1040841X.2020.1735991. Epub 2020 Mar 6.
Bacteria live in a polymicrobial community where it interacts with biotic and abiotic factors using specific signalling molecules. Acyl homoserine lactones, autoinducing peptides, bacteriocins and polyamines are a few signals documented for interspecies signalling. The signalling system could be used for a coordinated behaviour categorised as Quorum sensing (QS). QS is a term used to define a cell - cell communication process amongst bacteria that helps to gather cell density information and regulate gene expression accordingly. QS had been demonstrated to play a pivotal role in bacterial pathogenesis by regulating the expression of different virulence factors affecting adhesion, invasion and survival within a tissue. In the current review, we discuss the role of interspecies bacterial communication in pathogenicity. The molecules involved in the interspecies bacterial communication affecting virulence factors required for the establishment of infection have been discussed in detail to gain an insight for development of strategies that can be proposed to combat bacterial infections by attenuating their communication systems. The knowledge on the role of interspecies bacterial communication on virulence will assist in understanding the factors affecting symptomatic and asymptomatic infections.
细菌生活在一个微生物群落中，在这个群落中，它使用特定的信号分子与生物和非生物因素相互作用。酰高丝氨酸内酯、自诱导肽、细菌素和多胺是几种已被记录用于种间信号传递的信号。该信号系统可用于协调行为，被归类为群体感应（QS）。QS 是一个用于定义细菌之间细胞-细胞通信过程的术语，有助于收集细胞密度信息并相应地调节基因表达。QS 已被证明通过调节不同毒力因子的表达在细菌发病机制中发挥关键作用，这些毒力因子影响在组织内的粘附、入侵和存活。在本综述中，我们讨论了种间细菌通信在致病性中的作用。详细讨论了参与种间细菌通信的分子如何影响感染建立所需的毒力因子，以深入了解可以通过削弱其通信系统来提出的对抗细菌感染的策略。关于种间细菌通信对毒力的作用的知识将有助于理解影响有症状和无症状感染的因素。
