Giusti C
Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Clin Ter. 2020 Mar-Apr;171(2):e161-e166. doi: 10.7417/CT.2020.2207.
In patients with sarcoidosis, a lot of researches showed increased levels of the Th1 chemokine monokine induced by interferon (IFN)-γ (MIG) and its (C-X-C motif) receptor (CXCR)3 both in biopsy specimens and bronchoalveolar lavage fluid (BALF). In BALF these levels were associated with CD4(+) and total lymphocytes. Positive CXCR3 ligands staining were found in the alveolar macrophages, and in the epithelioid and giant cells in the sarcoid lungs. It can be assumed that in sarcoid lung the accumulation of Th1 lymphocytes is largely related to MIG. Moreover, the potential role of MIG as a biomarker of sarcoidosis and its severity were proven, given its circulating levels that correlated with the clinical course and gravity of the disease.
在结节病患者中，许多研究表明，活检标本和支气管肺泡灌洗（BALF）液中，由干扰素（IFN）-γ诱导的Th1趋化因子单核细胞趋化蛋白（MIG）及其（C-X-C基序）受体（CXCR）3水平均升高。在BALF中，这些水平与CD4(+)和总淋巴细胞相关。在结节病肺组织的肺泡巨噬细胞、上皮样细胞和巨细胞中发现CXCR3配体呈阳性染色。可以推测，在结节病肺中，Th1淋巴细胞的积聚很大程度上与MIG有关。此外，鉴于MIG的循环水平与疾病的临床进程和严重程度相关，其作为结节病生物标志物及其严重程度的潜在作用得到了证实。
