Ragusa F
Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Clin Ter. 2018 Nov-Dec;169(6):e308-e313. doi: 10.7417/CT.2018.2099.
Sarcoidosis is a systemic inflammatory disease, affecting any organ, and that can be discovered by accident in approximately 5% of cases. High levels of the type-1 helper (Th1)-dependent chemokine, monokine induced by interferon (IFN)-γ (MIG)/chemokine (C-X-C motif) ligand (CXCL)9, and its receptor CXCR3 have been reported in bronchoalveolar lavage and biopsy samples of patients with sarcoidosis. These elevated levels are related with the amount of CD4+ lymphocytes and total lymphocytes. Alveolar macrophages resulted stained positive for all CXCR3 ligands and produced elevated levels of these chemokines. It has been shown that the epithelioid and giant cells of the sarcoid lungs were stained positive for MIG, IFN-inducible T-cell α chemoattractant (I-TAC) and IFN-γ-inducible protein 10 (IP-10), suggesting that MIG plays an important role in the accumulation of Th1 lymphocytes in sarcoid lungs. In addition, serum levels of MIG were related with the severity of the disease, and a correlation between the serial measurements of MIG and the clinical course of the disease was shown, indicating MIG as a potentially useful biomarker of sarcoidosis and its severity.
结节病是一种全身性炎症性疾病，可累及任何器官，约5%的病例是偶然发现的。在结节病患者的支气管肺泡灌洗和活检样本中，已报告1型辅助性（Th1）依赖性趋化因子、干扰素（IFN）-γ诱导的单核细胞趋化蛋白（MIG）/趋化因子（C-X-C基序）配体（CXCL）9及其受体CXCR3水平升高。这些升高的水平与CD4+淋巴细胞和总淋巴细胞数量有关。肺泡巨噬细胞对所有CXCR3配体染色呈阳性，并产生这些趋化因子的升高水平。已表明结节病肺组织的上皮样细胞和巨细胞对MIG、IFN诱导的T细胞α趋化因子（I-TAC）和IFN-γ诱导蛋白10（IP-10）染色呈阳性，提示MIG在结节病肺组织中Th1淋巴细胞的积聚中起重要作用。此外，MIG的血清水平与疾病严重程度相关，并且显示MIG的系列测量值与疾病临床进程之间存在相关性，表明MIG是结节病及其严重程度的潜在有用生物标志物。
