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使用潜在剖面分析对国家阿尔茨海默病协调中心数据库中的轻度认知障碍异质性进行剖析。

Distilling Heterogeneity of Mild Cognitive Impairment in the National Alzheimer Coordinating Center Database Using Latent Profile Analysis.

机构信息

Department of Psychology, University of Southern California, Los Angeles.

VA San Diego Healthcare System, San Diego, California.

出版信息

JAMA Netw Open. 2020 Mar 2;3(3):e200413. doi: 10.1001/jamanetworkopen.2020.0413.

DOI:10.1001/jamanetworkopen.2020.0413
PMID:32142126
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7060488/
Abstract

This cohort study uses latent profile analysis to examine the variation in mild cognitive impairment among participants in the National Alzheimer Coordinating Center (NACC) database.

摘要

本队列研究采用潜在剖面分析来考察国家阿尔茨海默病协调中心（NACC）数据库参与者中轻度认知障碍的变化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1981/7060488/776a437d8956/jamanetwopen-3-e200413-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1981/7060488/776a437d8956/jamanetwopen-3-e200413-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1981/7060488/776a437d8956/jamanetwopen-3-e200413-g001.jpg

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本文引用的文献

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Disentangling Heterogeneity in Alzheimer's Disease: Two Empirically-Derived Subtypes.阿尔茨海默病的异质性解析：两种经验衍生的亚型。
J Alzheimers Dis. 2019;70(1):227-239. doi: 10.3233/JAD-190230.
2
Neuropsychological subtypes of incident mild cognitive impairment in the Mayo Clinic Study of Aging. Mayo 诊所老龄化研究中首发轻度认知障碍的神经心理学亚型。
Alzheimers Dement. 2019 Jul;15(7):878-887. doi: 10.1016/j.jalz.2019.03.014. Epub 2019 May 23.
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CSF tau and the CSF tau/ABeta ratio for the diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI).
他汀类药物起始治疗对痴呆风险估计影响的不确定性：使用多宇宙分析评估变异性来源。
Eur J Epidemiol. 2025 May 3. doi: 10.1007/s10654-025-01231-y.
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Latent profiles of team resilience and their relationship with team performance and turnover intentions among nurses.护士团队复原力的潜在概况及其与团队绩效和离职意愿的关系。
BMC Nurs. 2025 Feb 24;24(1):209. doi: 10.1186/s12912-025-02880-w.
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Subgroups of cognitive impairments in schizophrenia characterized by executive function and their morphological features: a latent profile analysis study.以执行功能为特征的精神分裂症认知障碍亚组及其形态学特征：一项潜在剖面分析研究。
BMC Med. 2025 Jan 8;23(1):13. doi: 10.1186/s12916-024-03835-9.
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Characterizing the clinical heterogeneity of early symptomatic Alzheimer's disease: a data-driven machine learning approach.表征早期症状性阿尔茨海默病的临床异质性：一种数据驱动的机器学习方法。
Front Aging Neurosci. 2024 Aug 12;16:1410544. doi: 10.3389/fnagi.2024.1410544. eCollection 2024.
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Cognition and Amyloid-β in Older Veterans: Characterization and Longitudinal Outcomes of Data-Derived Phenotypes.老年退伍军人的认知与β-淀粉样蛋白：数据衍生表型的特征及纵向结果
J Alzheimers Dis. 2024;99(1):417-427. doi: 10.3233/JAD-240077.
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Data-driven classification of cognitively normal and mild cognitive impairment subtypes predicts progression in the NACC dataset.基于数据驱动的认知正常和轻度认知障碍亚型分类可预测 NACC 数据集的进展。
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Neuropsychological syndromes associated with Alzheimer's/vascular dementia: a latent class analysis.与阿尔茨海默病/血管性痴呆相关的神经心理学综合征：一项潜在类别分析
J Alzheimers Dis. 2014;42(3):999-1014. doi: 10.3233/JAD-132147.
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Susceptibility of the conventional criteria for mild cognitive impairment to false-positive diagnostic errors.轻度认知障碍传统诊断标准出现假阳性诊断错误的易感性。
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