巴西萨尔瓦多的寨卡、登革热和基孔肯雅热虫媒病毒引起的母婴和先天性感染。
Maternal and congenital infections arising from Zika, dengue and Chikungunya arboviruses in Salvador, Brazil.
机构信息
Laboratório de Imunologia de Doenças Infecciosas, Faculdade de Farmácia, Universidade Federal da Bahia, Salvador-BA, CEP 40170-115, Brazil.
Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Ministério da Saúde, Salvador-BA, CEP 40296-710, Brazil.
出版信息
Trans R Soc Trop Med Hyg. 2020 Feb 7;114(3):222-225. doi: 10.1093/trstmh/trz098.
BACKGROUND
Salvador was one of the Brazilian cities most affected during the 2015 Zika virus (ZIKV) outbreak.
METHODS
A cross-sectional study was performed with enrolment of parturients and their newborns.
RESULTS
Positive IgM antibodies for ZIKV, dengue (DENV) and Chikungunya (CHIKV) were present in 6.9, 11.9 and 22.8% of the parturients, and IgG antibodies were detected in 72.3, 92.3 and 38.6%, respectively. No cases of DENV congenital infection were identified. ZIKV and CHIKV congenital infections were observed in 16.5 and 13% of newborns, respectively.
CONCLUSIONS
High exposure rates to the three arboviruses and the identification of newborns with ZIKV and CHIKV congenital infections reinforces the necessity of ZIKV and CHIKV prenatal and neonatal screening in endemic regions.
背景
萨尔瓦多是巴西受 2015 年寨卡病毒（ZIKV）疫情影响最严重的城市之一。
方法
本研究为一项横断面研究，纳入了产妇及其新生儿。
结果
6.9%的产妇血清中存在寨卡病毒（ZIKV）、登革热（DENV）和基孔肯雅热（CHIKV）IgM 抗体，相应的 IgG 抗体阳性率分别为 72.3%、92.3%和 38.6%。未发现 DENV 先天性感染病例。分别有 16.5%和 13%的新生儿存在寨卡病毒和基孔肯雅热的先天性感染。
结论
本研究中三种虫媒病毒的高暴露率以及新生儿存在寨卡病毒和基孔肯雅热的先天性感染，均提示在流行地区进行寨卡病毒和基孔肯雅热的产前和新生儿筛查十分必要。
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