Fundação Oswaldo Cruz (FIOCRUZ), Instituto Gonçalo Moniz, Salvador, BA, Brazil; Faculdade de Ciências Farmacêuticas, Laboratório de Análise Especializada em Biologia Molecular (LAEBM), Universidade Federal do Amazonas, Manaus, AM, Brazil; Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas (HEMOAM), Universidade do Estado do Amazonas (UEA), Manaus, AM, Brazil.
Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas (HEMOAM), Universidade do Estado do Amazonas (UEA), Manaus, AM, Brazil.
Braz J Infect Dis. 2024 Mar-Apr;28(2):103741. doi: 10.1016/j.bjid.2024.103741. Epub 2024 Apr 23.
Sickle Cell Disease (SCD) is a hereditary disease characterized by extravascular and intravascular hemolysis and clinical variability, from mild pain to potentially life-threatening. Arboviruses include mainly Zika (ZIKV), Chikungunya (CHKV), and Dengue (DENV) virus, and are considered a public and social health problem. The present cross-sectional observational study aimed to investigate the prevalence of arbovirus infection in SCD patients from two Brazilian cities, Salvador and Manaus located in Bahia and Amazonas states respectively. A total of 409 individuals with SCD were included in the study, and 307 (75.06 %) patients tested positive for DENV-IgG, 161 (39.36 %) for ZIKV-IgG, and 60 (14.67 %) for CHIKV-IgG. Only one individual was positive for DENV-NS1 and another for DENV-IgM, both from Salvador. No individuals had positive serology for ZIKV-IgM or CHIKV-IgM. Arbovirus positivity by IgG testing revealed that the SCD group presented high frequencies in both cities. Interestingly, these differences were only statistically significant for ZIKV-IgG (p = 0.023) and CHIKV-IgG (p = 0.005) among SCD patients from Manaus. The reshaping of arbovirus from its natural habitat by humans due to disorderly urban expansion and the ease of international Mobility has been responsible for facilitating the spread of vector-borne infectious diseases in humans. We found the need for further studies on arboviruses in this population to elucidate the real association and impact, especially in acute infection. We hope that this study will contribute to improvements in the personalized clinical follow-up of SCD patients, identifying the influence of arbovirus infection in severe disease manifestations.
镰状细胞病（SCD）是一种遗传性疾病，其特征是血管外和血管内溶血以及临床表现的可变性，从轻度疼痛到潜在的危及生命。虫媒病毒主要包括寨卡病毒（ZIKV）、基孔肯雅热病毒（CHKV）和登革热病毒（DENV），被认为是公共和社会卫生问题。本横断面观察性研究旨在调查来自巴西两个城市萨尔瓦多和玛瑙斯的 SCD 患者中虫媒病毒感染的流行情况，这两个城市分别位于巴伊亚州和亚马孙州。共有 409 名 SCD 患者纳入研究，其中 307 名（75.06%）患者 DENV-IgG 检测呈阳性，161 名（39.36%）ZIKV-IgG 检测呈阳性，60 名（14.67%）CHIKV-IgG 检测呈阳性。仅有一名来自萨尔瓦多的患者 DENV-NS1 和另一名患者 DENV-IgM 检测呈阳性。没有患者 ZIKV-IgM 或 CHIKV-IgM 血清学检测呈阳性。通过 IgG 检测发现，虫媒病毒阳性在两个城市的 SCD 组中均呈现高频率。有趣的是，在来自玛瑙斯的 SCD 患者中，这些差异仅在 ZIKV-IgG（p = 0.023）和 CHIKV-IgG（p = 0.005）方面具有统计学意义。由于无序的城市扩张和国际流动性的便利，人类改变了虫媒病毒的自然栖息地，这导致了虫媒传染病在人类中的传播。我们发现需要进一步研究该人群中的虫媒病毒，以阐明其真实的关联和影响，特别是在急性感染方面。我们希望这项研究将有助于改善 SCD 患者的个性化临床随访，确定虫媒病毒感染对严重疾病表现的影响。
